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ProteomicsLRRK2 mediates haloperidol-induced changes in striatal indirect pathway circuits
Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2Rs that are highly expressed in the striatum. Significant side effects of haloperidol, known as extrapyramidal symptoms, lead to motor deficits similar to those...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-25 | PXD053892 | Pride
Striatal Haloperidol Lrrk2 
ProteomicsProteome of R1441C and G2019S LRRK2 knock in mice after striatal motor learning task
LRRK2 mutations are associated with both familial and sporadic forms of Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 plays critical roles in regulating striatal function. Here, by using knock-in mouse lines that express the two most common LRRK2 pathogenic mutations—G2019S and R...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-15 | PXD037003 | Pride
Mouse Brain Striatum Lc-ms/ms 
ProteomicsThe Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons -striatal synaptosomes phosphoproteomic study
We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation, exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted quantitative phosphoproteomic Liquid Chromatography-Mass Spectro...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-19 | PXD065006 | Pride
Lc-ms Lrrk2 Striatal synaptosomes 
ProteomicsThe Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons-APEX2 proteome analysis
We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation, exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted axonal proteome analysis of a subcluster within vulnerable Aldh1...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-19 | PXD065003 | Pride
Lrrk2 Apex2 Proteome analysis 
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