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ProteomicsTRIM72 cross-linked by the higher-order assembly on the negatively charged liposome surface
Plasma membrane repair is a rapid cellular response for resealing of membrane for cell survival. In the early step of repair process, TRIM72 is known to a key initiator for facilitating patch membrane to the damaged membrane site. When acute membrane injury happens, TRIM72 is also known to sensitive...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD024946 | Pride
Cx-ms Trim72 Lc-ms/ms 
ProteomicsHuman TRIM72 localizes on the microsome
Membrane repair machinery is a unique process to maintain cell integrity. In the early step of repair process, TRIM72 facilitates the patch membranes to damaged sites for resealing membrane and protects cells from acute membrane injury. The TRIM72 is an E3 ubiquitin ligase belonging to tripartite mo...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD024978 | Pride
Microsome Trim72 Human 
UnknownThe natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II.
Mitochondria play a pivotal role in cancer bioenergetics and are considered a potential target for anticancer therapy. Considering the limited efficacy and toxicity of currently available mitochondria-targeting agents, it is necessary to develop effective mitochondria-targeting anticancer drugs. By ...
S-EPMC6813327 | biostudies-literature
UnknownFull-color micro-LED display with photo-patternable and highly ambient-stable perovskite quantum dot/siloxane composite as color conversion layers.
In this paper, we successfully fabricated color conversion layers (CCLs) for full-color-mico-LED display using a perovskite quantum dot (PQD)/siloxane composite by ligand exchanged PQD with silane composite followed by surface activation by an addition of halide-anion containing salt. Due to this su...
S-EPMC10039071 | biostudies-literature
UnknownAnalysis of Porcine Model of Fecal-Induced Peritonitis Reveals the Tropism of Blood Microbiome.
Recent studies have suggested the existence of a blood microbiome in the healthy host. However, changes in the blood microbiome upon bloodstream infection are not known. Here, we analyzed the dynamics of the blood microbiome in a porcine model of polymicrobial bacteremia induced by fecal peritonitis...
S-EPMC8435847 | biostudies-literature
UnknownStructure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Defects in plasma membrane repair can lead to muscle and heart diseases in humans. Tripartite motif-containing protein (TRIM)72 (mitsugumin 53; MG53) has been determined to rapidly nucleate vesicles at the site of membrane damage, but the underlying molecular mechanisms remain poorly understood. Her...
S-EPMC10643145 | biostudies-literature
UnknownDifferential epithelial and stromal LGR5 expression in ovarian carcinogenesis.
Lgr5 has been identified as a marker of the stem/progenitor cells in the murine ovary and oviduct by lineage tracing. However, little is known regarding LGR5 expression or its functional significance in human ovary tissues. Here, using RNA in situ hybridization and/or immunohistochemistry, we thorou...
S-EPMC9249864 | biostudies-literature
UnknownDenatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway.

Background

Bone remodeling is a critical process that maintains skeletal integrity, orchestrated by the balanced activities of osteoclasts, which resorb bone, and osteoblasts, which form bone. Osteoclastogenesis, the formation of osteoclasts, is primarily driven by NFATc1, a process activate...
S-EPMC11660935 | biostudies-literature
TranscriptomicsIdentification of cholangiocarcinoma-like gene expression traits in hepatocellular carcinoma
We performed gene expression profiling of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and mixed type of combined HCC and CC (CHC). In comparison of the profiles, a novel class of HCC expressing CC-like traits was identified. Gene expression profiling of 70 hepatocellular carcinoma (HCC)...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-15765 | biostudies-arrayexpress
UnknownCombined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy.
IgE is central to the development of allergic diseases, and its neutralization alleviates allergic symptoms. However, most of these antibodies are based on IgG1, which is associated with an increased risk of fragment crystallizable-mediated side effects. Moreover, omalizumab, an anti-IgE antibody ap...
S-EPMC9515155 | biostudies-literature
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