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ProteomicsProteomics of novel iPSC-derived vascular endothelial cells reveal extensive similarity with an immortalized human endothelial cell line
The vascular endothelium constitutes the inner lining of the blood vessel and is directly involved in the control of blood fluidity, vascular tone, platelet aggregation, regulation of immunity, inflammation, and angiogenesis. Malfunction and injuries of the endothelium can cause cardiovascular disea...
ORGANISM(S): Homo sapiens (Human) 
2023-07-05 | PXD038493 | Pride
Methylation Acetylation Endothelial cells Ipsc Phosphorylation 
Proteomics17 -estradiol impedes aortic root dilation and rupture in male Marfan mice
Thoracic aortic aneurysms have a higher prevalence in male patients compared to female patients. Marfan syndrome causes a hereditary form of TAA with dilation of the aortic root. Male patients with Marfan syndrome are more likely than women to have aortic dilation and dissection and mouse models o...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-14 | PXD037853 | Pride
Marfan syndrome Estrogen Sex differences Aneurysm 
ProteomicsMachine Learning Identifies Plasma Proteomic Signatures of Descending Thoracic Aortic Disease
Descending thoracic aortic aneurysms and dissections can go undetected until severe and catastrophic, and few clinical indices exist to screen for aneurysms or predict their risk of dissection or rupture. This study generated a plasma proteomic dataset from 150 patients with descending thoracic aort...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD041337 | Pride
Plasma proteomics Machine learning Type b dissection Descending aortic disease Thoracic aortic aneurysm 
ProteomicsIntegration of the whole proteome and transcriptome reveals a strong correlation between the protein and mRNA in a distinct population of cancer-derived EVs
Extracellular vesicles (EVs) are particles of different sizes, covered by a lipid bilayer membrane and containing highly heterogeneous cargo. Cancer cell-derived EVs have been the main object of an extensive investigation in the field because they carry cancer-specific molecular cargo and can promot...
ORGANISM(S): Homo sapiens (Human) 
2025-04-16 | PXD038011 | Pride
Cancer-derived ev Transcriptomics Proteomics Prostate cancer 
ProteomicsPilot data for Imputation, LC-MS/MS
Missing values in proteomic data sets have real consequences on downstream data analysis and reproducibility. Although several imputation methods exist to handle missing values, no single imputation method is best suited for a diverse range of data sets, and no clear strategy exists for evaluating i...
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD022996 | Pride
Dia-ms Ovarian cancer Imputation 
ProteomicsOvarian cancer imputation analysis, LC MS/MS
Missing values in proteomic data sets have real consequences on downstream data analysis and reproducibility. Although several imputation methods exist to handle missing values, no single imputation method is best suited for a diverse range of data sets, and no clear strategy exists for evaluating i...
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD023040 | Pride
Dia-ms Ovarianc cancer Tumor Stroma 
ProteomicsDilution Series imputation, LC MS/MS
Missing values in proteomic data sets have real consequences on downstream data analysis and reproducibility. Although several imputation methods exist to handle missing values, no single imputation method is best suited for a diverse range of data sets, and no clear strategy exists for evaluating i...
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD023012 | Pride
Dia-ms Ovarian cancer Imputation Dilution series 
ProteomicsDistinct phenotypes induced by acute hypoxia and TGF-β1 in human adult cardiac fibroblasts
Myocardial infarctions cause hypoxic injury to downstream tissue and a consequent fibrotic remodeling process to replace injured tissue with a scar. Scar formation occurs through phases of wound healing in which stimuli such as transforming growth factor-beta (TGF-β) drive cardiac fibroblasts to act...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD051197 | Pride
Hypoxia Transforming growth factor-beta Cardiac fibrosis Hypoxia-inducible factors Myocardial infarction 
ProteomicsHuman iPSC-derived mononuclear phagocytes restore cognition, neural health, and a subpopulation of hippocampal mossy cells in aging mice
Young blood or plasma and young bone marrow improves cognitive function in aged animals, though the cell type responsible for these regenerative effects remains unknown. This study evaluated the potential of induced pluripotent stem cell-derived mononuclear phagocytes (iMPs) as a therapeutic for ag...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD052723 | Pride
Neural health Induced pluripotent stem cells Hippocampus Mononuclear phagocytes Aging Cognitive decline 
TranscriptomicsGlobal Analysis of Yeast mRNPs
Proteins regulate gene expression by controlling mRNA biogenesis, localization, translation and decay. Identifying the composition, diversity and function of mRNPs (mRNA protein complexes) is essential to understanding these processes. In a global survey of S. cerevisiae mRNA binding proteins we ide...
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-18 | E-GEOD-46142 | biostudies-arrayexpress
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