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ProteomicsR1441G but not G201S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils
Gain-of kinase function variants in LRRK2 (leucine-rich repeat kinase 2) cause Parkinson’s disease (PD), albeit with incomplete and age-dependent penetrance, offering the prospect of disease-modifying treatment strategies via LRRK2 kinase inhibition. LRRK2 phosphorylates a subgroup of RabGTPases inc...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024898 | Pride
Parkinsosn's disease Prm Lrrk2 Rab-gtpase 
ProteomicsGlobal ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1
Mutations in PINK1 and Parkin lead to Parkinson’s disease. Cell culture-based studies have demonstrated that mitochondrial depolarisation induced by chemical uncouplers can activate PINK1 and Parkin activity. Very little is known on mitochondrial depolarisation signalling in post-mitotic neurons. We...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-15 | PXD027614 | Pride
Ubiqutylation Parkinsosn's disease Protoemics Pink1 
ProteomicsDiscovery of XL01126: A Potent, Fast, Cooperative, Selective, Oral bioavailable and Blood Brain Barrier Penetrant PROTAC Degrader of Leucine Rich Repeat Kinase 2 (LRRK2)
Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most promising targets for Parkinson’s Disease. LRRK2 targeting strategies have primarily focused on Type 1 kinase inhibitors, which however have limitations as the inhibited protein can interfere with natural mechanisms and lead to undesirable side...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-02 | PXD034055 | Pride
Parkinsosn's disease Tmt Lrrk2 Mass spectrometry Protac 
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