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MetabolomicsCholesterol dysregulation contributes to hematopoietic failure in parn-mutant zebrafish with implications for dyskeratosis congenita
Germline mutations in PARN cause dyskeratosis congenita (DC), an inherited bone marrow failure syndrome characterized by multilineage cytopenia and progression to myeloid disease. The mechanisms underlying this malignant transformation have not been fully elucidated. Here we show, using a loss-of-fu...
2026-09-29 | MTBLS15863 | MetaboLights
Transcriptomicspoly(A) specific ribonuclease (PARN)-dependent trimming of H ACA box RNAs
Microarray comprising probe sets for miRNAs and other small RNAs was used to determine which and how many small RNAs are potential substrates of poly(A) specific ribonuclease (PARN) in U2OS cells . Hybridization probes were generated by oligo(dT) priming.
ORGANISM(S): Homo sapiens 
2012-02-17 | E-MEXP-3344 | biostudies-arrayexpress
TranscriptomicsThe PARN deadenylase targets a discrete set of mRNAs for decay and regulates cell motility in mouse myoblasts
Almost all cellular mRNAs terminate in a 3M-bM-^@M-^Y poly(A) tail, the removal of which can induce both translational silencing and mRNA decay. Mammalian cells encode many poly(A)-specific exoribonucleases but their individual roles are poorly understood. Here, we undertook an analysis of the rol...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-35944 | biostudies-arrayexpress
TranscriptomicsPoly(A)-Specifc Ribonuclease 1 (PARN-1) Overexpression in Procyclic T. brucei
We sought to determine the effect of TbPARN-1 overexpression on global mRNA steady-state levels in T. brucei. The mRNA expression profile of tet-induced TbPARN-1 OvEx procyclic cells was compared to the mRNA profile of control cells (expressing tet-induced TAP tag alone) by microarray analysis. S...
ORGANISM(S): Trypanosoma brucei 
2010-03-04 | E-GEOD-20593 | biostudies-arrayexpress
ProteomicsPARN immunoprecipitates with CPSF6, in NCI-H520 Cells
The previous results suggest that PARN is involved in the early steps of miR-29a maturation. To identify factors that associate with and could recruit PARN to polyadenylated pri-miR-29a transcripts, we performed immunoprecipitation experiments in extracts of NCI-H520 cells with PARN antibody, follow...
ORGANISM(S): Homo sapiens (Human) 
2026-03-07 | PXD064050 | Pride
Cpsg6 In-gel digestion Ip Parn 
TranscriptomicsPARN mediates 3'-end trimming of Argonaute-cleaved precursor microRNAs
microRNAs (miRNAs) are typically generated as ~22-nucleotide double-stranded RNAs via processing of precursor hairpins by the RNase III enzyme Dicer, after which they are loaded into Argonaute (Ago) proteins to form RNA-induced silencing complex (RISC). However, the biogenesis of miR-451, an erythro...
ORGANISM(S): Danio rerio 
2013-11-13 | E-GEOD-51036 | biostudies-arrayexpress
GenomicsNovel PARN mutations in Hoyeraal-HReidarsson syndrome patients.
The deposited data correspond to the sequences of PARN gene obtained by whole exome sequencing in two patients carrying mutations in this gene as described in Benyelles et al. EMBO Mol Med 2019.. PARN is a poly(A)-specific ribonuclease that regulates the turnover of mRNAs and the maturation and sta...
EGAS00001003623 | EGA
GenomicsPARN-Driven Alternative Polyadenylation Regulates Immunoglobulin Homeostasis in Antibody-Secreting Cells [PARN ISO-seq]
PARN-Driven Alternative Polyadenylation Regulates Immunoglobulin Homeostasis in Antibody-Secreting Cells [PARN ISO-seq]
PRJNA1380298 | ENA
TranscriptomicsPoly(A)-specific ribonuclease (PARN) mediates 3' end maturation of the telomerase RNA component
Mutations in the poly(A) ribonuclease (PARN) gene cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita (DC)1,2, but how PARN deficiency impacts telomere maintenance is unclear. Here, using somatic cells and induced pluripotent stem (iPS) cells fro...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-71709 | biostudies-arrayexpress
GenomicsPARN is essential to GSIS in beta cells
PARN is essential to GSIS in beta cells
PRJNA1044780 | ENA
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