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TranscriptomicsMolecular profiling of functional interactions between pre-osteoblastic and breast carcinoma cells
The relationships between cancer cells and the microenvironment play a critical role in cancer growth and development. The bone stroma consists of mesenchymal stem cells (MSCs) and mature osteoblasts that promote cancer growth. Yet it is not completely understood what are the molecular processes gui...
ORGANISM(S): Mus musculus 
2014-11-23 | E-GEOD-34529 | biostudies-arrayexpress
TranscriptomicsInfiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury
Molecular profiling of infiltrating monocyte-derived macrophages versus resident kupffer cells following acute liver injury The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages (MF) in this process remains controversial mainly due to difficulties in distinguis...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-55606 | biostudies-arrayexpress
TranscriptomicsRedifferentiation of adult human M-NM-2 cells expanded in vitro by inhibition of the WNT pathway
In vitro expansion of adult human islet M-NM-2 cells is an attractive solution for the shortage of tissue for cell replacement therapy of type 1 diabetes. Using a lineage tracing approach, we have demonstrated that M-NM-2-cell-derived (BCD) cells rapidly dedifferentiate in culture and can proliferat...
ORGANISM(S): Homo sapiens 
2014-08-27 | E-GEOD-60803 | biostudies-arrayexpress
TranscriptomicsIsp7 is a novel regulator of amino acid uptake in the TOR signaling pathway
We show that the sensitivity of tsc mutant cells to rapamycin is mediated by TORC1 and can be suppressed by overexpression of the 2-oxoglutarate-Fe(II) dependent oxygenase, Isp7. We show that Isp7 is a novel regulator of amino acids uptake that acts via regulation of gene expression, both upstream a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-02-05 | E-GEOD-52759 | biostudies-arrayexpress
TranscriptomicsEffects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells, implications for Familial dysautonomia
Investigate IKAP importance in the development of neuronal cells, in order to understand Familial dysautonomia phenotype. Stable SHSY5Y cell lines, and control cells, in differentiated and un-differentiated conditions.
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-26458 | biostudies-arrayexpress
TranscriptomicsExpression data of genes from the gustatory cortex follwing novel taste learning
Novel taste memories, critical for animal survival, are consolidated to form long term memories which are dependent on translation regulation in the gustatory cortex We used microarray for identification of genes involved in novel taste learning at two time points- 1 and 3 hours following memory for...
ORGANISM(S): Rattus norvegicus 
2016-03-23 | E-GEOD-74546 | biostudies-arrayexpress
TranscriptomicsGlobal changes in gene expression of grapefruit peel tissue in response to the yeast biocontrol agent M. fructicola
This work explores the biochemical responses of surface wonds of fruit to yeast pathogens. Results indicate that significant expression changes occur following wounding and yeast application compared to wounded controls. These changes included a range of defense-related oxidative, signalling and sec...
ORGANISM(S): Citrus x paradisi 
2012-08-21 | E-GEOD-31669 | biostudies-arrayexpress
UnknownBeta Palmitate Improves Bone Length and Quality during Catch-Up Growth in Young Rats.
Not available
S-EPMC5537878 | biostudies-literature
TranscriptomicsDistinctive microRNA expression profile and potential funtional role in K562 cells
Our objective is to decipher a miRNA expression signature associated with Chronic myeloid leukemia (CML), with or without Imatinib or Dasatinib and compared to normal blood leukocytes, and to determine potential target genes and signaling pathways affected by these signature miRNAs. Background/Aims:...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-28825 | biostudies-arrayexpress
TranscriptomicsEIF4E AND EIF4GI HAVE DISTINCT AND DIFFERENTIAL IMPRINTS ON MULTIPLE MYELOMA'S PROTEOME AND SIGNALING
Accumulating data indicate translation plays a role in cancer biology, particularly its rate limiting stage of initiation. Despite this evolving recognition, the function and importance of specific translation initiation factors is unresolved. The eukaryotic translation initiation complex eIF4F cons...
ORGANISM(S): Homo sapiens 
2015-10-29 | E-GEOD-62821 | biostudies-arrayexpress
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