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GenomicsA CRISPR knockout screen revealed modulators of Chlamydia trachomatis parasitophorous vacuole stability
Chlamydia trachomatis is a prevalent bacterial cause of urogenital and ocular infections. The pathogen uses the effector CpoS to suppress a host defense response that aborts intracellular bacterial growth by inducing host cell death. We conducted a CRISPR knockout screen to identify host genes contr...
ORGANISM(S): Homo sapiens 
2025-07-10 | E-MTAB-15337 | biostudies-arrayexpress
OtherThe Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components.
Data from ProteomeXchange, PXD ID: PXD002113. File: 130514_LA_C_92_SAX8.mzml. Published as part of PLoS Pathog. 2015 Jun 4;11(6):e1004883 . From the Abstract: {{i}} Chlamydia trachomatis is an important human pathogen that replicates inside the infected host cell in a unique vacuole, the inclusion....
ORGANISM(S): Homo_sapiens_viruses, Human_female, Chlamydia_trachomatis_l2b_uch_1_proctitis, Chlamydia_trachomatis_l2c 
GPM32310020401 | GPMDB
Resource Reanalysis 
ProteomicsComparative proteomics of purified pathogen vacuoles correlates intracellular replication of Legionella pneumophila with the small GTPase Rap1
Legionella pneumophila is an opportunistic bacterial pathogen that causes a severe lung infection termed “Legionnaires’ disease”. The pathogen replicates in environmental protozoa as well as in macrophages within a unique membrane-bound compartment, the Legionella-containing-vacuole (LCV). Formation...
ORGANISM(S): Legionella 
2017-02-10 | PXD004797 | Pride
Host-pathogen interactions Macrophage Proteomics Phosphoinositide lipid Bacterial effector protein Legionella Type iv secretion Pathogen vacuole Small gtpase Amoeba Dictyostelium discoideum 
ProteomicsThe Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP and Sac1-dependent pathogen vacuole remodeling
The causative agent of Legionnaires’ disease, Legionella pneumophila, governs interactions with host cells by secreting ca. 330 different “effector” proteins. The facultative intracellular bacteria replicate in macrophages and amoeba within a unique compartment, the Legionella-containing vacuole (LC...
ORGANISM(S): Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Dictyostelium discoideum 
2023-02-21 | PXD034490 | Pride
Large fusion gtpase Oxysterol binding protein Legionella pneumophila Atlastin Legionnaires’ disease Host-pathogen interaction Pathogen vacuole Amoeba Dictyostelium discoideum 
ProteomicsQuorum sensing mediates the emergence of peripheral transmissive Legionella within the pathogen vacuole, selective escape and efficient spread
Legionella pneumophila, the causative agent of the severe pneumonia Legionnaires’ disease, replicates in free-living protozoa as well as in macrophages within a distinct compartment, the Legionella-containing vacuole (LCV). switches between a replicative, non-virulent and a motile, virulent phase. T...
ORGANISM(S): Legionella pneumophila subsp. pneumophila 
2021-08-09 | PXD023787 | Pride
Lc-ms Label-free quantification Legionella 
UnknownDynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche.
Not available
S-EPMC6931108 | biostudies-literature
ProteomicsProximity-labeling reveals novel host and parasite proteins at the Toxoplasma parasitophorous vacuole membrane
Cygan AM, Jean Beltran PM, Branon TC, Ting AY, Carr SA, Boothroyd JC. 2021. Toxoplasma gondii is a ubiquitous, intracellular parasite that envelopes its parasitophorous vacuole with a protein-laden membrane (PVM). The PVM is critical for interactions with the infected host cell such as nutrient tran...
ORGANISM(S): Toxoplasma Gondii (ncbitaxon:5811) Homo Sapiens (ncbitaxon:9606) 
2021-02-10 | MSV000086833 | MassIVE
ProteomicsProximity Labeling to Map Host-Pathogen Interactions at the Membrane of a Bacteria Containing Vacuole in Chlamydia trachomatis Infected Human Cells
Many intracellular bacteria, including the obligate intracellular pathogen Chlamydia trachomatis, grow within a membrane-bound “bacteria containing vacuole” (BCV). Secreted cytosolic effectors modulate host activity, but an understanding of the host-pathogen interactions that occur at the BCV membra...
ORGANISM(S): Chlamydia trachomatis Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) 
2019-10-25 | PXD015883 | Pride
Inclusion Chlamydia Proximity labeling Apex2 
ProteomicsProximity Labeling to Map Host-Pathogen Interactions at the Membrane of a Bacteria Containing Vacuole in Chlamydia trachomatis Infected Human Cells
Many intracellular bacteria, including the obligate intracellular pathogen Chlamydia trachomatis, grow within a membrane-bound “bacteria containing vacuole” (BCV). Secreted cytosolic effectors modulate host activity, but an understanding of the host-pathogen interactions that occur at the BCV membra...
ORGANISM(S): Chlamydia trachomatis Homo sapiens (Human) 
2019-10-25 | PXD015890 | Pride
Inclusion Chlamydia Proximity labeling Apex2 
TranscriptomicsA Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response. ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-38782 | biostudies-arrayexpress
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