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MetabolomicsLiquid Chromatography-Mass Spectrometry Quantification of Phytochemicals in Withania somnifera Using Data-Dependent Acquisition, Multiple-Reaction-Monitoring, and Parallel-Reaction-Monitoring with an Inclusion List

Characterization of botanical extracts by mass spectrometry-based metabolomics analysis helps in determining the phytochemical composition that underlies their bioactivity and potential health benefits, while also supporting reproducibility of effects in clinical trials. The quantification of sev...

2024-07-10 | MTBLS10418 | MetaboLights
TranscriptomicsTranscription profiling of human plasma cells in muscle in inclusion body myositis and polymyositis
Microarray data from muscle biopsy specimens from subjects with inclusion body myositis, polymyositis, and normals Experiment Overall Design: Microarray experiments
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3112 | biostudies-arrayexpress
Transcriptomicsinclusion body myositis
We investigated the gene and exon espression profiling in muscle biopsies of patients affected by inclusion body myosistis, polymyositis and in normal muscle controls
ORGANISM(S): Homo sapiens 
2014-02-02 | E-MTAB-2141 | biostudies-arrayexpress
MetabolomicsDietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology, increases oxidative stress, alters metabolism and causes gut dybiosis in APCmin mice
Not available
ORGANISM(S): Mus musculus 
ST002313 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human muscle specimens from 10 HIBM patients carrying the M712T Persian Jewish founder mutation to investigate hereditary inclusion body myopathy (HIBM)
HIBM is a neuromuscular disorder characterized by adult-onset, slowly progressive distal and proximal muscle weakness. Here, gene expression was measured in muscle specimens from 10 HIBM patients carrying the M712T Persian Jewish founder mutation in GNE and presenting with mild histological changes,...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12648 | biostudies-arrayexpress
ProteomicsC. trachomatis L2 inclusion proteome
Chlamydia trachomatis is an important human pathogen that replicates inside the infected host cell in a unique vacuole, the inclusion. The formation of this intracellular bacterial niche is essential for productive Chlamydia infections. Despite its importance for Chlamydia biology, a holistic view o...
ORGANISM(S): Homo sapiens (Human) 
2015-06-08 | PXD002113 | Pride
Chlamydia Inclusion Compartment Trachomatis Vacuole Lc-ms/ms 
TranscriptomicsCTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [RNA-Seq]
The goal of this study was to investigate the role of intragenic CTCF in alternative pre-mRNA splicing through a combined CTCF-ChIP-seq and RNA-seq approach. CTCF depletion led to decreased inclusion of weak upstream exons. CTCF ChIP-seq was performed in BJAB and BL41 B cell lines and normalized rel...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-31486 | biostudies-arrayexpress
ProteomicsMonomethylation of cytosolic 5’-nucleotidase 1A (cN1A) and its role in inclusion body myositis autoantigenicity
Inclusion body myositis (IBM) is a progressive muscle disease characterized by protein accumulation and anti-cN1A autoantibodies. This study aimed to identify post-translational modifications (PTMs) of cN1A in human skeletal muscle to understand its pathophysiological role. Using immunoaffinity puri...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD075326 | Pride
Monomethylation Ptm Inclusion body myositis Skeletal muscle Autoantibodies Cn1a Lc-ms/ms 
GenomicsMutations primarily alter the inclusion of alternatively spliced exons
Mutations primarily alter the inclusion of alternatively spliced exons
PRJNA637776 | ENA
ProteomicsExon inclusion signatures enable accurate estimation of splicing factor activity
Splicing factors control exon inclusion in messenger RNA, shaping transcriptome and proteome diversity. Their catalytic activity is regulated by multiple layers, making single-omic measurements on their own fall short in identifying which splicing factors underlie a phenotype. Here, we propose that ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-27 | PXD066623 | Pride
Cancer  alternative splicing  splicing factor  protein activity  viper  carcinogenesis 
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