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MetabolomicsIdentification of metabolites of trifunctional sphingomyelin (TFSM1) in HeLa 229 cells infected with Chlamydia trachomatis

Chlamydia trachomatis is an obligate intracellular bacterial pathogen and a leading cause of sexually transmitted infections worldwide. During its biphasic developmental cycle, infectious, non-replicative elementary bodies alternate with replicative reticulate bodies within a membrane-bound intra...

2026-08-10 | MTBLS15303 | MetaboLights
TranscriptomicsExpression data of A2EN cells during early stage of Chlamydia trachomatis infection
Chlamydia trachomatis is an obligate intracellular pathogen that causes trachoma and sextually transmitted disease in human. During early stage of infection, Chlamydia secreted bacterial effector proteins into host cell cytoplasm to help its entry and estabilishment of early replicated niche. We ide...
ORGANISM(S): Homo sapiens 
2014-04-09 | E-GEOD-54336 | biostudies-arrayexpress
TranscriptomicsDevelopmental stage specific metabolic and transcriptional activity of chlamydial elementary bodies and reticulate bodies in an axenic medium
Chlamydia trachomatis is a significant human pathogen yet their obligate intracellular nature severe restrictions upon research. Chlamydiae undergo a complex developmental cycle characterized by an infectious cell type known as the elementary body (EB) and an intracellular active replicative form ...
ORGANISM(S): Chlamydia trachomatis 
2012-11-20 | E-GEOD-39530 | biostudies-arrayexpress
TranscriptomicsGlycogen Accumulation in Chlamydia trachomatis is Controlled by its Plasmid Through Regulation of glgA
C. trachomatis possess a cryptic 7.5 kb plasmid of unknown function. Here we describe a comprehensive molecular and biological characterization of the naturally occurring plasmidless human Chlamydia trachomatis strain L2 (25667R). We found that despite minimal chromosomal polymorphisms the LGV L2 ...
ORGANISM(S): Chlamydia trachomatis 
2010-05-06 | E-GEOD-10199 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of Chlamydia trachomatis Serovar D genes under different in-vitro hormonal conditions
In this project we examined in-vitro effect of female sex hormones, estradiol and progesterone at average physiological concentration level on Chlamydia trachomatis gene expression level. Regulation of chlamydial gene expression by the female sex hormones oestradiol and progesterone was examined. A ...
ORGANISM(S): Chlamydia trachomatis 
2010-09-16 | E-GEOD-24119 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of the infectious and replicative forms of Chlamydia trachomatis L2
The obligate intracellular developmental cycle of Chlamydia trachomatis presents significant challenges in defining its proteome. In this study we have applied quantitative proteomics to both the intracellular reticulate body (RB) and the extracellular elementary body (EB) from C. trachomatis. We...
ORGANISM(S): Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) 
2016-06-28 | PXD003025 | Pride
Reticulate body Elementary body L2 Chlamydia trachomatis 
ProteomicsC. trachomatis L2 inclusion proteome
Chlamydia trachomatis is an important human pathogen that replicates inside the infected host cell in a unique vacuole, the inclusion. The formation of this intracellular bacterial niche is essential for productive Chlamydia infections. Despite its importance for Chlamydia biology, a holistic view o...
ORGANISM(S): Homo sapiens (Human) 
2015-06-08 | PXD002113 | Pride
Chlamydia Inclusion Compartment Trachomatis Vacuole Lc-ms/ms 
ProteomicsProtein profiling of Chlamydia trachomatis growth forms
By comprehensive quantitative proteome analysis we characterize the three growth forms elementary body (EB), reticulate body (RB) and aberrant reticulate body (ARB) of Chlamydia trachomatis genital strain D/UW-3/CX
ORGANISM(S): Chlamydia trachomatis (strain D/UW-3/Cx) 
2017-01-04 | PXD003883 | Pride
Rb Lc-msms Chlamydia trachomatis Eb Arb 
ProteomicsComplement deposition on Chlamydia trachomatis
Introduction Chlamydia trachomatis (C. trachomatis) is a Gram-negative bacterium and a common human pathogen. The World Health Organization (WHO) estimates that over 130 million people are infected with C. trachomatis globally each year and with increasing incidence. C. trachomatis causes long-lasti...
ORGANISM(S): Chlamydia trachomatis L2/434/Bu(f) Chlamydia trachomatis Homo sapiens (Human) Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) Chlamydia trachomatis L2/434/Bu(i) 
2020-11-23 | PXD019393 | Pride
C3 Complement Human Plasma Chlamydia trachomatis Lc-ms/ms 
ProteomicsChlamydia trachomatis effector Tri1 interacts with TRAF7 to displace native TRAF7 interactors
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections in the US and preventable blindness worldwide. This obligate intracellular pathogen replicates within a membrane-bound inclusion, but how it acquires nutrients from the host while avoiding detection by the innate...
ORGANISM(S): Homo sapiens (Human) Chlamydia trachomatis 
2024-05-05 | PXD049432 | Pride
Chlamydia trachomatis Apms 
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