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ProteomicsCDC-like Kinase 4 Deficiency Contributes to Pathological Cardiac Hypertrophy by Modulating NEXN Phosphorylation
Kinase-catalyzed phosphorylation plays crucial roles in numerous biological processes. CDC-like kinases (CLKs) are a group of evolutionarily conserved dual-specificity kinases that have been implicated in RNA splicing, glucose metabolism, diet-induced thermogenesis and so on. However, it is still la...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-05 | PXD029682 | Pride
Pathologic cardiac hypertrophy Cdc-like kinase 4 Phosphorylation Nexn 
TranscriptomicsTranscription profiling of mouse fetal heart from wild type and Estrogen-related Receptor gamma (ERRg) knockout strains
3 ventricles from E18.5 male mice were pooled for each array. Three arrays per genotype. Title: ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Post-Natal Heart; Abstract: At birth the heart undergoes a critical metabolic switch to transition from a predominant dependence o...
ORGANISM(S): Mus musculus 
2009-04-30 | E-GEOD-8199 | biostudies-arrayexpress
GenomicsBET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [ChIP-Seq]
Heart failure is driven by the interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. Coordinate activation of developmental, inflammatory, fibrotic and growth regulators underlies the hallmark phenotypes of pathologic cardiac hypertrophy and contra...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-46668 | biostudies-arrayexpress
TranscriptomicsBET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [NRVM Expression]
Heart failure (HF) is driven via interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. While pathologic gene transactivation in this context is known to be associated with recruitment of histone acetyl-transferases and local chromatin hyperacetylat...
ORGANISM(S): Rattus norvegicus 
2013-08-06 | E-GEOD-48111 | biostudies-arrayexpress
TranscriptomicsBET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [Mouse Heart Expression]
Heart failure (HF) is driven via interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. While pathologic gene transactivation in this context is known to be associated with recruitment of histone acetyl-transferases and local chromatin hyperacetylat...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-48110 | biostudies-arrayexpress
UnknownCaspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy.
Not available
S-EPMC6405540 | biostudies-literature
UnknownTransgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner.
Not available
S-EPMC4449792 | biostudies-literature
TranscriptomicsGene expression microarray profiling in mice hearts with pathological and physiological cardiac hypertrophy
Compelling evidence suggests that mitochondrial dysfunction contributes to the pathogenesis of heart failure, including defects in the substrate oxidation, and the electron transport chain (ETC) and oxidative phosphorylation (OXPHOS). However, whether such changes occur early in the development of h...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-56348 | biostudies-arrayexpress
GenomicsCIP, a cardioprotective factor, inhibits the transition from cardiac hypertrophy to heart failure
CIP, a cardioprotective factor, inhibits the transition from cardiac hypertrophy to heart failure
PRJNA799321 | ENA
UnknownContent of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy.
Not available
S-EPMC5664523 | biostudies-literature
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