Pathological complete response

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Unknown (2119)
Genomics (144)
Transcriptomics (125)
Proteomics (43)
Clinical (16)
Metabolomics (5)
Genomic (2)
Methylation profiling (2)
Models (1)
Other (1)

Organisms

Homo sapiens (127)
Chlamydomonas reinhardtii (39)
Pseudomonas canadensis (39)
Marchantia polymorpha subsp. ruderalis (39)
Methylocystis sp. (39)
Exiguobacterium sp. SH31 (39)
Porites pukoensis (39)
Bothrops insularis (39)
Bothrops jararaca (39)
Bothrops jararacussu (39)
Bothrops cotiara (39)
Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841 (39)
Dinosauria (39)
Trypanosoma vivax Y486 (39)
Streptomyces coelicolor (39)
Pseudomonas taiwanensis (39)
Burkholderia ubonensis MSMB22 (39)
Pseudomonas aeruginosa PA103 (39)
Artibeus jamaicensis (39)
Morchella importuna (39)
Clostridium autoethanogenum (39)
Microbacterium ginsengisoli (39)
Streptomyces sp. A494 Ydz-AH (39)
Strawberry leafy fruit phytoplasma (39)
Mus musculus (20)
Rattus norvegicus (11)
Helicobacter pylori (2)
Drosophila melanogaster (1)
Alexandromys fortis (1)
Cricetulus griseus (1)

Organisms

Homo sapiens (91)
Mus musculus (5)
Rattus norvegicus (4)
Saccharomyces cerevisiae (1)
gut metagenome (1)

Repository

ENA (115)
biostudies-arrayexpress (74)
geo (59)
pride (39)
EGA (24)
MetaboLights (5)
MassIVE (3)
dbGaP (2)
BioModels (1)
iProX (1)

Tissue

Cell culture (11)
Muscle cell (2)
Monocyte (2)
Breast (2)
Lung (2)
Retina (2)
Blood plasma (2)
Epithelium of esophagus (1)
Barrett's esophagus (1)
Rectum (1)
C2C12 cell (1)
Cartilage tissue (1)
Arterial system endothelium (1)
Oligodendrocyte (1)
Neuron maturation (1)
Skeletal muscle fiber (1)
Endothelial cell (1)
Cartilage (1)
Mature microglial cell (1)
Mature astrocyte (1)
Breast cancer cell (1)
Primary cell (1)
Saliva (1)
Blood (1)
Oocyte (1)
B cell (1)
Cerebrospinal fluid (1)
Fibroblast (1)
Microglial cell (1)
Blood serum (1)

Disease

Colorectal Neoplasms (4)
Rectal Neoplasms (3)
Breast cancer (3)
Locally advanced rectal cancer (2)
Colorectal cancer (2)
Acute leukemia (2)
Locally advanced breast carcinoma (LABC; non-inflammatory) (1)
Patients with locally advanced rectal cancer planned for pre-operative CRT followed by definitive surgery and post operative chemotherapy (1)
Gastric cancer (1)
Rectal cancer (1)
Carcinoma (1)
Colorectal cancer (1)
Myofibrillar myopathy 1 (1)
Esophagus adenocarcinoma (1)
Stroke (1)
Multiple sclerosis (1)
Herpes simplex (1)
Allergic asthma (1)
Inflammation (1)
Narcolepsy (1)
Rheumatoid arthritis (1)
Pancreatic cancer (1)
Cardiovascular system disease (1)
Disease free (1)
Wounds and Injuries (1)

Technology Type

Mass Spectrometry (39)
Shotgun proteomics (19)
Bottom-up proteomics (10)
Data-dependent acquisition (8)
Affinity purification coupled with mass spectrometry proteomics (6)
Mass spectrometry (4)
Data-independent acquisition (3)
Gel-based experiment (2)
Top-down proteomics (2)
Mass spectrometry assay (1)
SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Orbitrap Fusion Lumos (3)
Liquid Chromatography MS - negative - reverse phase (3)
Liquid Chromatography MS - positive - reverse phase (3)
Illumina NovaSeq 6000 (2)
Illumina HiSeq 4000 (2)
Liquid Chromatography MS - negative - hilic (2)
Liquid Chromatography MS - positive - hilic (2)
Nanostring GeoMx® spatial profiler (1)
Unknown (1)
E.Z.N.A. Total RNA Kit I (Omega Bio-tek) (1)
NA (1)
- (1)
NextSeq 500 (1)
Direct infusion MS - positive (1)
Gas Chromatography MS - positive (1)

Publication Date

2025 (20)
2026 (17)
2022 (14)
2012 (14)
2014 (13)
2023 (12)
2024 (11)
2010 (11)
2015 (8)
2011 (8)
2008 (8)
2021 (8)
2013 (7)
2020 (6)
2016 (6)
2009 (5)
2007 (4)
2019 (4)
2018 (2)
2005 (2)
2004 (1)
2017 (1)

CHEBI ID

CHEBI:77462 (2)
CHEBI:85568 (2)
CHEBI:85566 (2)
CHEBI:72965 (2)
CHEBI:72966 (2)
CHEBI:66848 (2)
CHEBI:30860 (2)
CHEBI:17234 (2)
CHEBI:73039 (2)
CHEBI:70749 (2)
CHEBI:67064 (2)
CHEBI:64541 (2)
CHEBI:64544 (2)
CHEBI:67076 (2)
CHEBI:67077 (2)
CHEBI:72347 (2)
CHEBI:64524 (2)
CHEBI:64519 (2)
CHEBI:64525 (2)
CHEBI:64526 (2)
CHEBI:64446 (2)
CHEBI:66858 (2)
CHEBI:65303 (2)
CHEBI:37084 (2)
CHEBI:17712 (2)
CHEBI:26984 (2)
CHEBI:16010 (2)
CHEBI:30768 (2)
CHEBI:73024 (2)
CHEBI:18211 (2)

Metabolite Name

Valine (2)
Pipecolic acid (2)
Kynurenic acid (2)
Citrulline (2)
7-Methylguanine (2)
Glyceric acid (2)
Threonic acid (2)
Proline (2)
Oxalic acid (2)
Maltose (2)
1-Methylnicotinamide (2)
Malic acid (2)
Leucine (2)
(S)-3-methyl-2-oxovaleric acid (1)
4-aminobutanoic acid (1)
L-alpha-aminobutyric acid (1)
Furan-2,5-dicarboxylic acid (1)
Beta-Hydroxybutyric acid (1)
Indolepropionic acid (1)
HPHPA (1)
Indole acetic acid (1)
P-Hydroxyhippuric acid (1)
2-Hydroxy-3-methylvaleric acid (1)
3,4-Dihydroxybutyric acid (1)
3-hydroxyisovaleric acid (1)
Ribofuranose (1)
3-Indoleacetic acid (1)
SM 42:3 (1)
SM 42:2 (1)
SM 42:1 (1)

First Public Date

2014 (21)
2023 (15)
2026 (14)
2025 (13)
2024 (12)
2022 (11)
2021 (9)
2019 (6)
2020 (5)
2017 (4)
2015 (3)
2018 (1)
2013 (1)

Modelling Approach

Computational model (1)

Study status

Recruiting (8)
Not yet recruiting (3)
Completed (3)
Terminated (2)

Lab affiliation

Biomedical Research, Novartis Pharma AG (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, 3584 CH Utrecht, Netherlands. (1)
Department of Dermatology Johns Hopkins School of Medicine (1)
Federal University of Sao Paulo, Functional Proteomics Laboratory, Sao Jose dos Campos, Sao Paulo, Brazil. (1)
Musculoskeletal Biology 1, Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom. (1)
Novartis Institutes for BioMedical Research, Basel, Switzerland (1)
Laboratory of Pediatrics, UMCG, The Netherlands (1)
1. Gavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA 2. Department of Physiology and Biophysics, School of Medicine, University of California Irvine, CA (1)
Department of Neurobiology and Developmental Science, University of Arkansas for Medical Sciences, Little Rock, AR (1)
BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University (1)
Parsons Group Randall Centre for Cell & Molecular Biophysics King's College London UK (1)
Sorbonne Université, Inserm, Institut de Myologie, Centre de Recherche en Myologie, Paris, France. (1)
ReMedy International Research Agenda Unit, University of Warsaw, Warsaw 02-097, Poland; Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland (1)
Laboratoire PRISM Universite de Lille (1)
Centre for Craniofacial and Regenerative Biology, King's College London, Guy's Hospital, United Kingdom (1)
University of Padova, Department of Surgery, Oncology and Gastroenterology (1)
ICAR-CIFE, Mumbai (1)
Head of Proteomics, CRUK Scotland Institute, Glasgow (1)
Toulouse Institute for infectious and inflammatory diseases (Infinity), University of Toulouse, CNRS, INSERM, UPS, Toulouse, France. Department of Immunology, Toulouse University Hospitals, Toulouse, France. (1)
Genome Integrity laboratory, Medical Research Council Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, The University of Oxford, Oxford, UK (1)
Discipline of Pathology, Charles Perkins Centre, University of Sydney, Australia (1)
Associate Professor Dept. of Pathology and Laboratory Medicine HSRF 218, University of Vermont Larner College of Medicine Burlington, Vermont, 05405, USA (1)
Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China (1)
Boston Children's Hospital (1)
Head of the Laboratory for Vascular Biology, Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation (1)
Newcastle Univeristy (1)
Medizinisches Proteom-Center, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany (1)
Department of Systems Biology, Harvard Medical School (1)
University of Geneva, Faculty of Medicine, 1211 Geneva, Switzerland (1)
Dr. Alexander Schmidt Proteomics Core Facility Biozentrum, University of Basel Klingelbergstrasse 50/70 CH-4056 Basel / Switzerland (1)

Keyword

Rectum (2)
Capecitabine (2)
Oxaliplatin (2)
Resectable Rectal Cancer (1)
GI - Colorectal Neoadjuvant (1)
Monoclonal antibodies (1)
Preoperative radiotherapy (1)
Programmed Cell Death 1 Receptor (1)
Surgical Oncology (1)
ELVORINE (1)
FLUOROURACILE (1)
Non-resectable hepatic metastases (1)
Neoadjuvant Therapy (1)
Anti-EGFR (1)
First-line treatment (1)
Immune Checkpoint Inhibitors (1)
Neoadjuvant therapy (1)
Radiation (1)
Oncology (1)
Colorectal (1)
Neoadjuvant (1)
Folic Acid (1)
Panitumumab (1)
CAMPTO (1)
Antibodies (1)
Antibodies, Monoclonal (1)
Irinotecan (1)
Celecoxib (1)
Leucovorin (1)
Bevacizumab (1)

IsPrivate

False (1)

Submitter Keywords

FAIR-AIML (1)
Machine Learning Model (1)

Study type

Transcription profiling by array (57)
Interventional (11)
RNA-seq of coding RNA (5)
Comparative genomic hybridization by array (4)
Observational (4)
Cell line - Single-cell sequencing (1)
Unknown experiment type (1)
Human - One-color microarray (1)
Animal - High-throughput sequencing (1)
Genotyping by array (1)
Spatial transcriptomics by high-throughput sequencing (1)
Other (1)
Methylation profiling by array (1)
Other (1)

Release Date

2025 (410)
2022 (317)
2023 (309)
2024 (289)
2021 (213)
2020 (138)
2019 (105)
2018 (73)
2016 (59)
2017 (53)
2015 (43)
2014 (42)
2026 (42)
2012 (27)
2013 (25)
2011 (14)
2010 (11)
2009 (7)
2008 (5)
2007 (4)
2005 (3)
2006 (2)
2004 (1)
2003 (1)

Location

China (7)
Australia (2)
Japan (2)
Jordan (1)
France (1)
Belgium (1)
United States (1)

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Oxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and patho...

2023-05-09 | MTBLS6965 | MetaboLights

GSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer

The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers. The relationship of GSTP1 expression and GSTP1 prom...

ORGANISM(S): Homo sapiens

2012-03-20 | E-GEOD-32646 | biostudies-arrayexpress

A specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer

Background: MicroRNAs (miRNAs) are small, non-coding, RNA molecules which regulate numerous cellular processes. Specific miRNA may be abnormally down-regulated or up-regulated in colorectal cancer and have been found associated with prognosis or response to treatments. However, no study has ever ad...

ORGANISM(S): Homo sapiens

2012-04-24 | E-GEOD-29298 | biostudies-arrayexpress

Sammut2022 - Multi-omic machine learning model to predict pathological complete response for breast cancer neoadjuvant therapy

In this publication, researchers investigated the intricate relationship between breast cancers and their microenvironment, specifically focusing on predicting treatment responses using multi-omic machine learning model. They collected diverse data types including clinical, genomic, transcriptomic, ...

2023-08-28 | BIOMD0000001075 | BioModels

Machine Learning Model FAIR-AIML

Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS

As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...

2021-10-12 | MTBLS2130 | MetaboLights

DNA methylation-based classifier to predict pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal carcinomas.

PRJNA548688 | ENA

FOSL2 promotes intertumoral infiltration of T Cells and increase pathological complete response rates in locally advanced rectal cancer patients

PRJNA878771 | ENA

Plasma proteome signature to predict outcome of breast cancer patients receiving neoadjuvant chemotherapy

The purpose of this study is to find candidate biomarkers by analyzing proteins with differential amounts in 17 breast cancer patients’ plasmas with pathological complete response and 34 breast cancer patients’ plasmas without pathological complete response.

ORGANISM(S): Homo sapiens (Human)

2022-02-15 | PXD028251 | Pride

Human Lc-msms Pathological complete response Breast cancer Neoadjuvant chemotherapy Proteome Plasma

DNA methylation-based classifier to predict pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal carcinomas.

Locally advanced rectal cancer (LARC) patients have been treated with a pre-operative multimodal regimen based on 5-fluorouracil and radiotherapy (nCRT) followed by surgery. Patients that achieve pathological complete response (pCR) present better overall survival and lower rates of recurrence. Subs...

ORGANISM(S): Homo sapiens

2021-06-08 | GSE132668 | GEO

Transcription profiling of breast cancer samples to predict response to anthracycline/taxane chemotherapy .

EORTC 10994 phase III breast cancer clinical trial comparing FEC (5-fluorouracil, cyclophosphamide, epirubicin) with ET (epirubicin, docetaxel). 161 needle biopsies of locally advanced or large operable breast tumours were hybridised to Affymetrix X3P chips. The array data from the ER negative ...

ORGANISM(S): Homo sapiens

2008-06-15 | E-GEOD-6861 | biostudies-arrayexpress

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