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MetabolomicsCharacterizing ex vivo models for studying lipid metabolism in triple negative breast cancer

Lipid metabolism drives cancer progression but is difficult to model using conventional methods. In vivo models provide circulating lipids, but are costly and low throughput, while in vitro models lack sufficient lipid availability in culture media. Here, we evaluate the chick chorioallantoic mem...

2026-07-16 | MTBLS13377 | MetaboLights
TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
ProteomicsOf mice and models: Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer
- Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, whi...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD054649 | Pride
Proteogenomics Proteomics Mass spectrometry Patient-derived xenograft models (pdx) Ovarian cancer 
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
TranscriptomicsGenomic profiling of patient-derived xenografts identify high level “passenger” gene aberrations associated with better prognosis in non-small cell lung cancer
Patient-derived tumor xenografts (PDXs) increasingly are being used as preclinical models to study human cancers and to evaluate novel therapeutics, as they reflect clinical cancers more closely than established tumor cell lines. With >100 PDXs established from resected non-small cell lung carcinoma...
ORGANISM(S): Mus musculus 
2016-10-26 | E-GEOD-68929 | biostudies-arrayexpress
ProteomicsLeveraging Patient-Derived Models to Identify Novel Treatment Options in High-Grade Serous Ovarian Cancer
Ovarian cancer (OC) remains one of the leading causes of gynecological cancer related. Despite its histological and genetic heterogeneity, standard treatment has remained largely unchanged, relying on cytoreductive surgery followed by platinum-taxol chemotherapy. Although the introduction of PARP in...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD065781 | Pride
Lc-ms Drug resistance Tmt Hirief Bcl-xl Ovarian cancer 
GenomicsPatient-derived models of prostate cancer
Patient-derived models of prostate cancer
PRJNA1000653 | ENA
GenomicsPatient-derived models of prostate cancer
Patient-derived models of prostate cancer
PRJNA1000652 | ENA
ProteomicsUnraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts
Resistance to androgen deprivation therapies leads to metastatic castration-resistant prostate cancer (mCRPC) of adenocarcinoma (AdCa) origin that can transform to emergent aggressive variant prostate cancer (AVPC) which has neuroendocrine (NE)-like features. To this end, we used LuCaP patient-deriv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-09 | MSV000092139 | MassIVE
TranscriptomicsRNA-Seq of ALDH positive and ALDH negative cells from patient-derived xenograft models of colon cancer
Colon cancer patient-derived xenograft (PDX) models were processed to single cells and sorted by FACS (BD FACS Aria II) for ALDH activity (Aldefluor assay) and DAPI. ALDH Negative and ALDH Positive cells from each PDX model were collected and lysed in RLT buffer and processed for RNA using the RNeas...
ORGANISM(S): Homo sapiens 
2021-01-11 | E-MTAB-8927 | biostudies-arrayexpress
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