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ProteomicsCharacterisation of a cell-free myxoid liposarcoma patient-derived xenograft scaffold model
Myxoid liposarcoma (MLS) is the second most common type of liposarcoma, and today few model systems to study the disease exists. To be able to model the disease in vitro, cell-free scaffolds from MLS patient-derived xenograft (PDX) models were generated. The MLS scaffolds were then used as a 3D grow...
ORGANISM(S): Homo sapiens (Human) 
2024-05-08 | PXD023792 | Pride
Cancer Human Fus-ddit3 expression and tumor microenvironment 
ProteomicsProteomics of cell-free patient-derived scaffolds from breast cancer identify clinically relevant imprinted proteins and cancer-progressing properties
Breast cancer is a heterogenous disease that is difficult to model in vitro. Frozen primary breast cancers were decellularised to generate patient-derived scaffolds which are used to model 3D growth for cancer cell lines. The cell-free cancer microenvironments in the patient-derived scaffolds influe...
ORGANISM(S): Homo sapiens (Human) 
2024-04-18 | PXD042671 | Pride
Patient-derived scaffold Breast cancer 3d model Quantitative liquid chromatography-mass spectrometry/mass spectrometry Tumor microenvironment 
ProteomicsDIA-based proteomic profiling of iPSC-derived neurons with SEC16A mutation
SEC16A encodes a scaffold protein that organizes the endoplasmic reticulum (ER) exit sites, specialized ER subdomains that mediate export of newly synthesized proteins and regulate early secretory pathway steps. The role of SEC16A in human nervous system diseases has not been established yet. Here, ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-30 | PXD083732 | Pride
Human Patient ipsc-derived neurons 
GenomicsTranscriptional dysregulation associated with chromatin accessibility of iPSC and hepatocytes derived from a Cornelia de Lange syndrome patient (sWGS)
Cornelia de Lange syndrome (CdLS) is a rare genetic disease associated with cohesinopathy. A novel iPSC line was generated from the CdLS patient carrying a heterozygous missense point-mutation of the NIPBL gene. iPSC lines prepared from the healthy parents and the mutation-corrected isogenic cel...
ORGANISM(S): Homo sapiens 
2023-07-20 | E-MTAB-12989 | biostudies-arrayexpress
ProteomicsPatient-derived scaffolds uncover breast cancer promoting properties of the microenvironment
Tumor cells interact with the microenvironment that specifically supports and promotes tumor development. Key components in the tumor environment have been linked to various aggressive cancer features and can further influence the presence of subpopulations of cancer cells with specific functions, i...
ORGANISM(S): Homo sapiens (Human) 
2020-06-25 | PXD018367 | Pride
Differentiation Cancer stem cells Breast cancer Infiltration Malignancy Scaffold 
ProteomicsDiscovery of potential biomarkers in plasma-derived extracellular vesicles of a heart-transplanted chronic Chagas disease patient
Chagas disease (CD) is emerging in nonendemic countries. Biomarkers for earlier therapeutic response assessment in chronic CD patients are much needed. Here, we describe the first proteomic profiling of plasma-derived extracellular vesicles from a heart-transplanted patient with chronic CD and show ...
ORGANISM(S): Trypanosoma cruzi Homo sapiens (Human) 
2021-09-08 | PXD014668 | Pride
Proteomic analysis Extracellular vesicles Chagas disease Biomarkers Trypanosoma 
ProteomicsLabel-free proteomics quantification of pancreatic ductal adenocarcinoma patient-derived xenografts with treatment combining Gemcitabine and nab-Paclitaxel
Tumor-stroma interactions are critical in pancreatic ductal adenocarcinoma (PDAC) progression and therapeutics. Patient-derived xenograft (PDX) models faithfully recapitulate tumor-stroma interactions in PDAC, but conventional antibody-based immunoassay is largely inadequate to resolve or quantify t...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-07-05 | PXD042267 | Pride
Lc-ms/ms patient-derived xenografts species-deconvolved proteomics 
ProteomicsPhosphoproteomics of Matrigel-embedded samples
Phosphoproteomics data of Matrigel-embedded HCT116 spheroid, and patient-derived colorecral cancer organoid
ORGANISM(S): Homo Sapiens (human) 
2019-02-24 | PXD009032 | JPOST Repository
UnknownA Patient-Derived Scaffold-Based 3D Culture Platform for Head and Neck Cancer: Preserving Tumor Heterogeneity for Personalized Drug Testing.
Not available
S-EPMC12524346 | biostudies-literature
Unknown5-fluorouracil treatment of patient-derived scaffolds from colorectal cancer reveal clinically critical information.
Not available
S-EPMC9102939 | biostudies-literature
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