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Topisomerase 1 (TOP1), an essential enzyme in humans, plays a critical role in relaxation of DNA supercoils during replication and transcription. The TOP1 reaction cycle involves an obligate TOP1-DNA covalent complex intermediate (TOP1cc), which is stabilized by TOP1 poisons like camptothecin. While...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD055870 | Pride
In this study, we address the difference in adult fibroblasts developmentally originating from different germ layers. Closer, we focussed on HOX gene expression and the potential influence of physiological and pathological conditions in postnatal life. Here we specifically focused on fibroblasts fro...
ORGANISM(S): Homo sapiens 
Changes in sensory gene expression may underly seasonal changes in behavior. To accompany other research on seasonal changes in coloration and behavior in the seasonally plastic common buckeye butterfly Junonia coenia, we examined how gene expression in eyes differs between wild butterflies caught...
ORGANISM(S): Junonia coenia 
In this study, we address the difference in adult fibroblasts developmentally originating from different germ layers. Closer, we focussed on HOX gene expression and the potential influence of physiological and pathological conditions in postnatal life. Here we specifically focused on fibroblasts fr...
ORGANISM(S): Homo sapiens 
Bulk RNA-seq of young and aged livers following influenza A virus infection
Bulk RNA-seq of young and aged lungs following influenza A virus infection
Stable ETV5 knockdown SH-SY5Y were used to investigate the role of ETV5 in vitro and in vivo. Libraries for mRNA sequencing were prepared using the TruSeq stranded mRNA sample prep kit (Illumina), involving polyA-selection, fragmentation, adapter ligation, reverse transcription and PCR amplification...
ORGANISM(S): Homo sapiens 
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