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ProteomicsIn vivo characterization of the bacterial intramembrane-cleaving protease RseP using the heme binding tag-based assay iCliPSpy
Purified, putative unprocessed and processed MBPmut-TNFa fusion proteins were analyzed by LC-MS. The average molecular weights of the eluted MBPmut-TNFa fusion proteins obtained by deconvolution of the ESI-MS spectra are given. For MBPmut-TNFa preparations from “Empty vector control” and “RseP-Myc H...
ORGANISM(S): Escherichia coli 
2023-03-20 | PXD038785 | Pride
Tnf Fusion protein Intact mass analysis Lc-msms Intermembrane protease 
ProteomicsAnalysis of Amyloid Plaque Composition in two mouse models of Alzheimer’s disease
MALDI mass spectrometry imaging (MSI) enables label-free, spatially resolved analysis of a wide range of analytes in tissue sections. Quantitative analysis of MSI datasets is typically performed on single pixels or manually assigned regions of interest (ROI). However, many sparse, small objects such...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-15 | PXD020824 | Pride
Alzheimer Maldi Ms imaging Amyloid plaques Linear positive mode Abeta 
ProteomicsTissue protease activity with MALDI MSI
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Mus Musculus (ncbitaxon:10090) 
MSV000086102 | MassIVE
UnknownSarcopenia during androgen-deprivation therapy for prostate cancer.
Not available
S-EPMC3434987 | biostudies-literature
ProteomicsIntegrative single-plaque analysis reveals signature Aβ and lipid profiles in the Alzheimer’s brain
Utilizing multimodal mass spectrometry imaging (MSI) combined with machine learning techniques, this study investigates the molecular heterogeneity of amyloid-β (Aβ) plaques and associated lipid profiles in post-mortem brain samples from Alzheimer’s disease (AD) and amyloid-positive cognitively unaf...
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD049325 | Pride
Alzheimer’s disease Amyloid-β Maldi ms imaging Gangliosides Machine learning 
UnknownDenosumab and bone metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer: exploratory analyses by baseline prostate-specific antigen doubling time.
Not available
S-EPMC3795889 | biostudies-literature
ProteomicsTissue protease activity with MALDI MSI
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2020-08-06 | PXD011104 | Pride
Protease activity Maldi-msi 
MetabolomicsTargeting PI3K inhibitor resistance in breast cancer with metabolic drugs

Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (Her2-) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI3K inhibitor Alpelisib. This treatment significantly improves ...

2026-08-21 | MTBLS11671 | MetaboLights
GenomicsGenomic Sequencing of Medulloblastoma

Medulloblastomas are the most common malignant brain tumors in children. Identifying and understanding the genetic events that drive these tumors is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct ...

phs000504.v1.p1 | EGA
TranscriptomicsTranscription profiling by high throughput of Blumeria gramis during infection of Barley
The aim of this experiment was to investigate the transcriptomic variation within Blumeria graminis f. sp. hordei during infection of Barley. SOLiD RNA-seq data was generated for 6 samples, three from the epiphytic hyphae and three from the haustoria within the epidermis.
ORGANISM(S): Blumeria graminis 
2012-06-11 | E-MTAB-682 | biostudies-arrayexpress
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