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ProteomicsPosition-specific N- and O-glycosylation of the reactive centre loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin
Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues through the proteolytic cleavage of an exposed reactive centre loop (RCL) by neutrophil elastase (NE). We previously demonstrated that RCL-localised Asn347-linked N-glycans impact NE proteolysis, but a comp...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD046405 | Pride
Glycosylation O-glycosylation Corticosteroid-binding globulin Cortisol N-glycosylation Proteolysis Reactive centre loop Neutrophil elastase 
TranscriptomicsIdentification of a responsive gene set to evaluate the potential impact of seismic exposure on Atlantic salmon (Salmo salar) inner ear
Considerable interest and controversy has arisen over the potential effects of seismic surveys carried out during exploration for oil and gas deposits. Regarding fish, there is a concern that intense sound sources, such as seismic airguns, may injure their auditory system. In this study, salmonid cD...
ORGANISM(S): Salmo salar 
2012-02-28 | E-GEOD-33257 | biostudies-arrayexpress
UnknownShort-term behavioural responses of Atlantic bluefin tuna to catch-and-release fishing.
Not available
S-EPMC9487900 | biostudies-literature
UnknownConsensus on treatment for residents in long-term care facilities: perspectives from relatives and care staff in the PACE cross-sectional study in 6 European countries.
Not available
S-EPMC6714096 | biostudies-literature
UnknownGenetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
Not available
S-EPMC2922003 | biostudies-literature
UnknownTiger sharks support the characterization of the world's largest seagrass ecosystem.
Not available
S-EPMC9626626 | biostudies-literature
UnknownMulticenter, Prospective, Randomized Controlled Trial of High-Sensitivity Cardiac Troponin I-Guided Combination Angiotensin Receptor Blockade and Beta-Blocker Therapy to Prevent Anthracycline Cardiotoxicity: The Cardiac CARE Trial.
Not available
S-EPMC10655910 | biostudies-literature
ProteomicsThe BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation
BRD4 regulates gene transcription in complex eukaryotes, in part through the binding of its tandem bromodomains to acetylated lysine residues found in histones and transcription factors. Despite pharmacological inhibition of these binding events showing significant promise in preclinical studies, cl...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD064221 | Pride
Histone Nucleosome Ptms Acetylation Brd4 
UnknownRandomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1.
Not available
S-EPMC5207004 | biostudies-literature
ProteomicsThe structure and composition of native human nucleosomes
In this study, we analysed the composition of histone modifications on native nucleosomes purified from HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD064241 | Pride
Ptms Cryoem Nucleosomes Histones 
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