Sort   by:  
 Page size 
TranscriptomicsTrancriptomic profiling of HCT116 colon cancer cells with or without PBRM1 knock-down by RNAi
To investigate the influence of PBRM1 on gene expression, we performed RNA-seq in HCT116 colon cancer cells with or without PBRM1 knock-down by RNAi (both shRNA and siRNA approaches were used), and identified differentially expressed genes in PBRM1 knock-down cells compared to control cells, which s...
ORGANISM(S): Homo sapiens 
2018-01-30 | E-MTAB-5566 | biostudies-arrayexpress
ProteomicsPBRM1 loss in kidney cancer imbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation
PBRM1 is the 2nd-most frequently inactivated gene in clear cell renal cell cancer (RCC) but the oncogenic mechanisms, and hence methods for correction, are unclear. PBRM1 is a subunit of the PBAF coactivator complex that transcription factors use to reposition nucleosomes (‘open chromatin’) for gene...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD020544 | Pride
Pbrm1 pax8 differentiation 
TranscriptomicsPBRM1 Knockdown in RCC Cell Lines
PBRM1 was found to be mutated in a high percentage of clear cell RCCs. We performed knockdown of PBRM1 via siRNA and compared with scrambled control in three different RCC cell lines. PBRM1 siRNA and mock treated cell lines were normalized together with 'hypoxic' clear cell renal tumors and normal r...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-22316 | biostudies-arrayexpress
ProteomicsPBRM1 directs PBAF to pericentromeres and centromeres to constrain transcription and protect genome integrity
The specialized structure of the centromere is critical for effective chromosome segregation, but its repetitive nature and configuration makes it vulnerable to rearrangements. Centromere fragility can drive tumorigenesis, but protective mechanisms preventing fragility are still not fully understood...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-01-06 | PXD043209 | Pride
Pbrm1 Transcription Pericentromeres Centromeres Pbaf 
GenomicsNMuMG PBRM1 ChIP-seq
NMuMG PBRM1 ChIP-seq
PRJNA1365246 | ENA
GenomicsNMuMG PBRM1 ATAC-seq
NMuMG PBRM1 ATAC-seq
PRJNA1271058 | ENA
ProteomicsPBRM1-deficient PBAF complexes target de novo genomic loci to activate pro-survival genes in clear cell renal cell carcinoma (PBRM1 dataset)
PBRM1 is lost in 40% of clear cell renal cell carcinomas (ccRCC) and the combined loss of VHL and PBRM1 drives ccRCC tumorigenesis. PBRM1 is an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and despite its well-established role as a tumor suppressor, we have limited under...
ORGANISM(S): Homo Sapiens (human) 
2021-07-24 | PXD020554 | JPOST Repository
GenomicsGenome-wide chromatin profiles of PBRM1 [RNA-Seq]
Genome-wide chromatin profiles of PBRM1 [RNA-Seq]
PRJNA640299 | ENA
TranscriptomicsDNA Copy-Number Alterations in clear-cell Renal Cell Carcinoma (ccRCC) Tumors and Tumorgrafts for samples deficient in BAP1 or PBRM1
Renal cell carcinoma (RCC) exhibits some unusual features and genes commonly mutated in cancer are rarely mutated in clear-cell RCC (ccRCC), the most common type. The most prevalent genetic alteration in ccRCC is the inactivation of the tumor suppressor gene VHL. Using whole-genome and exome sequenc...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-25540 | biostudies-arrayexpress
GenomicsGenome-wide chromatin profiles of PBRM1 [ChIP-Seq]
Genome-wide chromatin profiles of PBRM1 [ChIP-Seq]
PRJNA640096 | ENA
Sort   by:  
 Page size