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ProteomicsStructure of nucleosome-bound human PBAF complex
BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for transcription activation. Despite previous structural studies and recent advance of SWI/SNF family complexes, it remains incompl...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036708 | Pride
Mass spectrometry analysis of acetylated nucleosome Pbaf Ncp Lc-ms 
TranscriptomicsBrd7, a novel PBAF-specific SWI/SNF subunit, is required for gene activation and repression in embryonic stem cells
The composition of chromatin remodeling complexes dictates how these enzymes control transcriptional programs and cellular identity. Here, we investigate the composition of SWI/SNF complexes in embryonic stem cells (ESCs). In contrast to differentiated cells, ESCs have a biased incorporation of cert...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-7791 | biostudies-arrayexpress
ProteomicsPBRM1 directs PBAF to pericentromeres and centromeres to constrain transcription and protect genome integrity
The specialized structure of the centromere is critical for effective chromosome segregation, but its repetitive nature and configuration makes it vulnerable to rearrangements. Centromere fragility can drive tumorigenesis, but protective mechanisms preventing fragility are still not fully understood...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-01-06 | PXD043209 | Pride
Pbrm1 Transcription Pericentromeres Centromeres Pbaf 
UnknownStructure of nucleosome-bound human PBAF complex.
Not available
S-EPMC9741621 | biostudies-literature
GenomicsPBAF associates with repressed chromatin to enable REST occupancy (RNA-Seq)
PBAF associates with repressed chromatin to enable REST occupancy (RNA-Seq)
PRJNA1150637 | ENA
GenomicsPBAF associates with repressed chromatin to enable REST occupancy [ATAC-Seq]
PBAF associates with repressed chromatin to enable REST occupancy [ATAC-Seq]
PRJNA1235845 | ENA
GenomicsPBAF associates with repressed chromatin to enable REST occupancy (ChIP-seq)
PBAF associates with repressed chromatin to enable REST occupancy (ChIP-seq)
PRJNA1138230 | ENA
ProteomicsPBRM1-deficient PBAF complexes target de novo genomic loci to activate pro-survival genes in clear cell renal cell carcinoma (PBRM1 dataset)
PBRM1 is lost in 40% of clear cell renal cell carcinomas (ccRCC) and the combined loss of VHL and PBRM1 drives ccRCC tumorigenesis. PBRM1 is an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and despite its well-established role as a tumor suppressor, we have limited under...
ORGANISM(S): Homo Sapiens (human) 
2021-07-24 | PXD020554 | JPOST Repository
ProteomicsPBRM1-deficient PBAF complexes target de novo genomic loci to activate pro-survival genes in clear cell renal cell carcinoma (BRG1 dataset)
PBRM1 is lost in 40% of clear cell renal cell carcinomas (ccRCC) and the combined loss of VHL and PBRM1 drives ccRCC tumorigenesis. PBRM1 is an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and despite its well-established role as a tumor suppressor, we have limited under...
ORGANISM(S): Homo Sapiens (human) 
2021-07-24 | PXD020553 | JPOST Repository
GenomicsPBRM1 directs PBAF to pericentromeres and protects centromere integrity [RNA-Seq]
PBRM1 directs PBAF to pericentromeres and protects centromere integrity [RNA-Seq]
PRJNA985722 | ENA
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