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ProteomicsCysteine Redox proteomics of PDIA6 over-expressing skeletal muscle
To investigate the role of PDIA6 on changes to specific cysteine residues with altered redox status and insulin senstivity, we overexpressed either GFP control or FLAG-PDIA6 throughout the musculature of 4-day old male C57BL/6J mice via intraperitoneal injection with MyoAAV (Fig. 5F). At 8 weeks of ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD075204 | Pride
Pdia6 Iodo-tmt 
GenomicsRNAseq facilitates quantitative analysis of wildtype, pdia6 -/- and focad -/- zebrafish livers transcriptome
RNAseq facilitates quantitative analysis of wildtype, pdia6 -/- and focad -/- zebrafish livers transcriptome
PRJNA714665 | ENA
GenomicsEHMT1/KMT1D drives neointima formation via epigenetic repression of the PPARγ–PDIA6 axis
EHMT1/KMT1D drives neointima formation via epigenetic repression of the PPARγ–PDIA6 axis
PRJNA1469614 | ENA
GenomicsPDIA6 supports IL6-responsive STAT3 signaling and prolifera-tion in head and neck squamous cell carcinoma
PDIA6 supports IL6-responsive STAT3 signaling and prolifera-tion in head and neck squamous cell carcinoma
PRJNA1521873 | ENA
TranscriptomicsRNAseq facilitates quantitative analysis of wildtype, pdia6 -/- and focad -/- zebrafish livers transcriptome
pdia6 knockout zebrafish and focad knockout zebrafish were generated to model liver diseases observed in human patient. Livers were harvested from wt, pdia6 -/- and focad -/- adult zebrafish for RNASeq to study its transcriptome profile.
ORGANISM(S): Danio rerio 
2022-04-01 | GSE168961 | GEO
ProteomicsMelanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture(RIC) to characterize the melanoma RBPome and uncover novel RBPs involved in melanoma progression. Comparison of RIC profi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD029927 | Pride
Rbp Mass spectrometry Melanoma 
GenomicsMelanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
PRJNA731851 | ENA
TranscriptomicsPDIA6 supports IL6-responsive STAT3 signaling and prolifera-tion in head and neck squamous cell carcinoma
This study investigated transcriptional changes associated with PDIA6 loss in head and neck squamous cell carcinoma cells. CAL33 cells carrying control or PDIA6-targeting CRISPR/Cas9 constructs were subjected to bulk RNA sequencing, with three independent biological replicates per group. Differentia...
ORGANISM(S): Homo sapiens 
2026-10-03 | GSE345765 | GEO
UnknownPDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.
Not available
S-EPMC4714551 | biostudies-literature
TranscriptomicsEHMT1/KMT1D drives neointima formation via epigenetic repression of the PPARγ–PDIA6 axis
Neointima formation underlies restenosis and other occlusive vascular diseases, yet the epigenetic regulators that drive this process remain poorly understood. We aimed to define the role of the histone methyltransferase EHMT1 in neointima formation and to delineate its downstream mechanisms. Here, ...
ORGANISM(S): Homo sapiens 
2026-07-13 | GSE333141 | GEO
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