Pediatric brain tumors

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Unknown (1558)
Genomics (346)
Transcriptomics (227)
Methylation profiling (28)
Proteomics (22)
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Genomic (3)
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Clinical (1)

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Homo sapiens (325)
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Organisms

Homo sapiens (157)
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Repository

ENA (228)
geo (167)
biostudies-arrayexpress (127)
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pride (18)
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Tissue

Brain (11)
Cell culture (4)
Permanent cell line cell (2)
Astrocyte (1)
Cerebellum (1)
Cerebrospinal fluid (1)
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Choroid plexus epithelium (1)
Choroid plexus papilloma cell (1)
Endothelial cell (1)
Epithelial cell (1)
Stem cell (1)

Disease

Brain cancer (7)
Medulloblastoma (4)
Normal (4)
Atypical teratoid / rhabdoid tumor (1)
Normal frontal (1)
Normal cerebellum (1)
Medulloblastoma, large-cell (1)
Primitive neuroectodermal tumor (1)
Glioblastoma (1)
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Invasive Ductal Carcinoma (1)
Astrocytoma III (1)
Central nervous system cancer (1)
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Neoplasms (1)
Atypical choroid plexus papilloma (1)
Brain glioblastoma multiforme (1)
Childhood medulloblastoma (1)
Choroid plexus carcinoma (1)
Choroid plexus papilloma (1)
Neuroblastoma (1)

Technology Type

Mass Spectrometry (18)
Shotgun proteomics (12)
Illumina HiSeq 2000 (4)
Bottom-up proteomics (3)
Mass spectrometry (2)
Data-dependent acquisition (2)
Illumina HiSeq 2000, Illumina Infinium HumanMethylation450 BeadChip, Affymetrix expression array, ILLUMINA (1)
Illumina HiScanSQ, ILLUMINA (1)
Illumina HiSeq 2500 (ILLUMINA), AB SOLiD System (ABI_SOLID) (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer IIx (1)
Illumina HiSeq 2500 (1)
Affinity purification coupled with mass spectrometry proteomics (1)
Gel-based experiment (1)
SRM/MRM (1)

Instrument Platform

NextSeq 500 (3)
Orbitrap Fusion (2)
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Sony SH800S Cell Sorter (1)
Sony SH8000S Cell Sorter (1)
Scanning of was performed on an Axon 4000B scanner (1)
Illumina iScan (1)
Axon- GenePix4000B (1)
Illumina NovaSeq 6000 (1)
Orbitrap Exploris 240 (1)
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Publication Date

2024 (34)
2014 (32)
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2026 (30)
2013 (26)
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2010 (20)
2011 (17)
2015 (15)
2012 (13)
2022 (13)
2019 (11)
2021 (10)
2020 (9)
2017 (9)
2016 (8)
2018 (6)
2009 (6)
2008 (4)
2007 (3)
2006 (1)

CHEBI ID

CHEBI:16077 (1)
CHEBI:22211 (1)
CHEBI:17822 (1)
CHEBI:15721 (1)
CHEBI:26271 (1)
CHEBI:25094 (1)
CHEBI:18237 (1)
CHEBI:22660 (1)
CHEBI:22653 (1)
CHEBI:48928 (1)
CHEBI:27570 (1)
CHEBI:18186 (1)
CHEBI:26986 (1)
CHEBI:16811 (1)
CHEBI:17234 (1)
CHEBI:28300 (1)
CHEBI:24898 (1)
CHEBI:25017 (1)
CHEBI:15428 (1)
CHEBI:15741 (1)
CHEBI:6650 (1)
CHEBI:28044 (1)
CHEBI:27266 (1)
CHEBI:16449 (1)
CHEBI:29016 (1)
CHEBI:78682 (1)
CHEBI:15422 (1)
CHEBI:18012 (1)
CHEBI:32816 (1)
CHEBI:16027 (1)

Metabolite Name

GLY (1)
ASP (1)
MET (1)
Fructose-1,6-Bisphosphate (1)
Sedoheptulose-7-Phosphate (1)
AlphaKetoglutarate (1)
Glucose-1-Phosphate (1)
GLU (1)
ALA (1)
Adenosine triphosphate (ATP) (1)
ASN (1)
TRP (1)
SER (1)
THR (1)
GLN (1)
VAL (1)
PRO (1)
ILE (1)
LEU (1)
LYS (1)
ARG (1)
HIS (1)
PHE (1)
TYR (1)
6-Phosphogluconate (1)
Malate (1)
Adenosine monophosphate (1)
Phosphoenolpyruvate (1)
Aconitic acid (1)
Adenosine diphosphate (ADP) (1)

First Public Date

2025 (43)
2024 (35)
2023 (29)
2026 (25)
2014 (23)
2022 (17)
2019 (14)
2017 (11)
2020 (8)
2018 (7)
2021 (6)
2015 (5)
2013 (3)
2016 (2)

Study status

Recruiting (1)

Study type

Transcription profiling by array (72)
Comparative genomic hybridization by array (16)
Methylation profiling by array (16)
Unknown experiment type (5)
Genotyping by array (4)
RNA-seq of coding RNA (4)
ChIP-seq (3)
Human - Methylation microarray (1)
Human - High-throughput sequencing (1)
Transcription profiling by RT-PCR (1)
Other (1)
RNA-seq of coding RNA from single cells (1)
Methylation profiling by high throughput sequencing (1)
Interventional (1)

Release Date

2023 (197)
2022 (182)
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2020 (160)
2021 (158)
2024 (131)
2019 (111)
2018 (80)
2017 (80)
2015 (76)
2014 (73)
2016 (68)
2013 (51)
2012 (37)
2011 (31)
2010 (31)
2026 (23)
2009 (16)
2008 (8)
2007 (4)
2004 (3)
2003 (2)
2006 (1)
2001 (1)
2000 (1)

Lab affiliation

Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany (2)
Attending Physician Medical Director, Brain Tumor Institute Principal Investigator, Center for Cancer and Immunology Research, Children Research Institute Associate Professor of Pediatrics - The George Washington University School of Medicine and Health Sciences Executive co-Chair, Childrens Brain Tumor Network www.CBTN.org (1)
Baylor College of Medicine Houston, Texas (1)
Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany (1)
Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany & Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany (1)
Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD. (1)
Epigenetics and Cell Fate Centre CNRS UMR7216 – Université Paris Cité Lamarck B building, 4th floor, room 413 35, rue Hélène Brion 75205 Paris Cedex 13 +33157278981 (1)
Institute for Molecular Medicine I, Medical Faculty, Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany (1)
Ist. G. Gaslini (1)
Jack Cole Chair in Pediatric Hematology/Oncology Professor, Department of Pediatrics McGill University (1)
Janusz Rak MD, PhD Jack Cole Chair in Pediatric Hematology/Oncology Professor, Department of Pediatrics McGill University The Research Institute of the McGill University Health Centre Montreal Children's Hospital 1001 Decarie Blvd, Office # E M1 2244 Montreal, Quebec, H4A 3J1 Phone: (514) 412-4400 ext-office: 76240; -lab: 76220; Fax (514) 412-4331 (1)
Mass Spectrometry and Proteomics facility (LSMP) Institut Curie PSL Research University FRANCE (1)
Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Switzerland. (1)
School of Biosciences University of Sheffield Sheffield, S10 2TN United Kingdom (1)
Section mass-spectrometry and proteomics Diagnostic Center, Research Campus N27 Room 00.008 Martinistr. 52 20246 Hamburg (1)
The University of Sydney (1)
Tumor Biology Research Program, Basic Research Unit, Research Department, Children's Cancer Hospital Egypt 57357 (1)

Location

United States (1)

Keyword

First-In-Class Investigational Agent (1)
Peri-Nucleolar Compartment (PNC) (1)
Effective therapies against metastasis (1)
Oral Administration (1)
Maximum Recommended Starting Dose (1)

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Transcription profiling by array of human tumor cells with stem-like properties isolated from pediatric brain tumors

Background
Primitive brain tumors are the first cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pe...

ORGANISM(S): Homo sapiens

2011-09-07 | E-MEXP-2910 | biostudies-arrayexpress

Comparative genomic hybridization by array of human tumor cells with stem-like properties isolated from pediatric brain tumors

ORGANISM(S): Homo sapiens

2011-09-07 | E-MEXP-2909 | biostudies-arrayexpress

Expression data from human brain tumors and human normal brain

The characteristics of immune cells infiltrating pediatric brain tumors is largely unexplored. A better understanding of these characteristics will provide a foundation for development of immunotherapy for pediatric brain tumors. Gene expression profiles were used to identify immune marker gene that...

ORGANISM(S): Homo sapiens

2013-08-25 | E-GEOD-50161 | biostudies-arrayexpress

Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes

Rhabdoid tumors (RTs) are aggressive tumors of early childhood that occur most often in brain (AT/RTs) or kidney (KRTs). Regardless of location, they are characterized by loss of functional SMARCB1 protein, a component of the SWI/SNF chromatin remodeling complex. The aim of this study was to determi...

ORGANISM(S): Homo sapiens

2013-01-21 | E-GEOD-35493 | biostudies-arrayexpress

Proteogenomic Discovery of Neoantigens Facilitates Personalized Multi-antigen Targeted T cell Immunotherapy for Brain Tumors

Neoantigen discovery in pediatric brain tumors is hampered by their low mutational burden and scant tissue availability. We developed a low-input proteogenomic approach combining tumor DNA/RNA sequencing and mass spectrometry proteomics to identify tumor-restricted (neoantigen) peptides arising from...

ORGANISM(S): Homo sapiens (Human)

2021-11-02 | PXD029082 | Pride

Transcription profiling of human SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue

Gene expression profiling of SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue.

ORGANISM(S): Homo sapiens

2010-08-09 | E-MEXP-2351 | biostudies-arrayexpress

NanoString immune profiling of pediatric brain tumors

PRJNA946766 | ENA

Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas

The outcome for children with high-grade gliomas (HGG) remains dismal, with a two-year survival rate of only 10-30%. Approximately half of pediatric HGGs are diffuse intrinsic pontine glioma (DIPG), a brainstem tumor that arises almost exclusively in children. Genome-wide analyses of copy number i...

ORGANISM(S): Mus musculus

2013-11-06 | E-GEOD-46190 | biostudies-arrayexpress

MicroRNAs characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia

MicroRNAs (miRNAs) regulate activity of protein-coding genes including those involved in hematopoietic cancers. The goal of the current study was to explore which miRNAs are unique for seven different subtypes of pediatric acute lymphoblastic leukemia (ALL). Therefore, the expression levels of 397 m...

ORGANISM(S): Homo sapiens

2011-02-11 | E-GEOD-23024 | biostudies-arrayexpress

Immunotherapy for Pediatric Brain Tumors.

Not available

S-EPMC5664064 | biostudies-literature

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