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MetabolomicsDetermining predictive metabolomic biomarkers of meniscal injury in dogs with cranial cruciate ligament disease

OBJECTIVES: This study used hydrogen nuclear magnetic resonance spectroscopy (1H NMR) for the first-time to examine differences in the metabolomic profile of stifle joint synovial fluid from dogs with cranial cruciate ligament rupture with and without meniscal injuries, in order ...

2025-08-14 | MTBLS6050 | MetaboLights
MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
ProteomicsMulti-omics approach to identify age-related changes in mesenchymal stem cells
Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstra...
ORGANISM(S): Homo sapiens (Human) 
2016-02-16 | PXD001952 | Pride
Human mesenchymal stem cells Label-free quantification 
ProteomicsViperin; regulating chondrogenic differentiation via CXCL10 protein secretion
Mutations in the RMRP gene are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, it is not clear why mutations in the RMRP gene lead to skeletal dysplasia. Viperin is a known substrate of RMRP. Sinc...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-15 | PXD006999 | Pride
Mouse Viperin Chondrogenic differentiation 
MetabolomicsMetabolomic and Proteomic Stratification of Equine Osteoarthritis

Osteoarthritis (OA) is characterised by loss of articular cartilage, synovial membrane dysfunction and subchondral sclerosis. Few studies have used a global approach to stratify equine synovial fluid (SF) molecular profiles according to OA severity. SF was collected from 58 metacarpophalangeal (M...

2025-10-16 | MTBLS1645 | MetaboLights
ProteomicsMulti-omics approach to identify age-related changes in mesenchymal stem cells
Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079981 | MassIVE
ProteomicsRibosomal proteome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3
Ribosomal proteome of SW1353 cells cultured in the presence of the 10 ng/ml TGF-β3 and control condition was assessed.
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD046114 | Pride
Ribosomal proteome Tgfb Sw1353 
ProteomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. The underlying pathogenesis of OA is yet to be fully elucidated with no OA specific biomarkers in clinical u...
ORGANISM(S): Equus caballus (Horse) 
2020-08-03 | PXD017153 | Pride
Metabolomics Mass spectrometry Nuclear magnetic resonance Cartilage Proteomics Osteoarthritis 
ProteomicsInflammation and response to bacterial infection as potential drivers of equine odontoclastic tooth resorption and hypercementosis: A proteomic insight
Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a relatively recently described dental disorder, commonly found in horses above the age of 15 years old (Carsten Staszyk et al. 2008). The disease was first categorised as EOTRH in 2008, following the identification of clinical cas...
ORGANISM(S): Equus caballus (Horse) 
2025-06-16 | PXD051310 | Pride
Dental Teeth Equine Proteomics 
ProteomicsThe Synovial Fluid Proteome Differentiates between Septic and Nonseptic Articular Pathologies
Presently few studies have investigated the proteomic profile of equine synovial fluid (SF) using high mass resolution mass spectrometer and in-solution trypsin digestion and to our knowledge none have investigated protein profile changes septic SF in any species. In this study we have used mass spe...
ORGANISM(S): Equus caballus (Horse) 
2019-05-01 | PXD011276 | Pride
Synovial fluid Proteomics Sepsis 
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