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Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a transcriptional coactivator that has previously been shown to collaborate with nuclear receptors. Evidence from other groups suggest that PELP1 may stimulate transcription by displacing the linker histone H1 and/or by recruiting the l...
ORGANISM(S): Homo sapiens 
We examined the role of PELP1 in E2-ER-mediated transcription in the hippocampus under conditions of GCI by perfroming global transcriptome analysis. E2-treated FLOX and PELP1 FBKO mice were subjected to GCI followed by 24 h reperfusion and the isolated RNA was utilized for RNA-seq analysis. Our res...
ORGANISM(S): Mus musculus 
PELP1 is a scaffold protein with diverse cellular functions including its role as the central scaffold for the human Rix1 complex (PELP1, WDR18, TEX10, and SENP3). We have reconstituted the mammalian Rix1 complex and identified a sub-complex made of the conserved Rix1 domain of PELP1 and the WDR18 p...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037729 | Pride
PELP1 regulate medulloblastoma progression via NF-κB pathway
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a transcriptional coactivator that has previously been shown to collaborate with nuclear receptors. Evidence from other groups suggest that PELP1 may stimulate transcription by displacing the linker histone H1 and/or by recruiting the l...
ORGANISM(S): Homo sapiens 
2014-04-24 | GSE22254 | GEO
MCF-7 cell RNA-seq analysis of PELP1-induced gene expression
RNA-seq was performed on MCF-7 cells expressing vector control (LXSN), PELP1-wt, and PELP1-cyto
ORGANISM(S): Homo sapiens 
2021-07-05 | GSE126776 | GEO
We examined the transcriptional changes modulated by Proline Glutamic acid and Leucine rich Protein 1 (PELP1) by performing global transcriptome analysis. Daoy medulloblastoma cells were transduced with control shRNA or PELP1 shRNA lentiviral particles and the RNA was isolated and utilized for RNA-s...
ORGANISM(S): Homo sapiens 
2025-05-01 | GSE131347 | GEO
The therapeutic potential and significance of the PELP1 signaling pathway in hepatocellular carcinoma
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