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ProteomicsS6K1 Phosphoproteome in Tsc1-null mouse kidney iMCD3 cells
Loss of Tsc1 in the kidneys gives rise to rapid polycystogenesis and kidney failure due to the hyperactivation of mTOR complex I (mTORC1). One of the major downstream targets of mTORC1 is S6K1, which is responsible for driving many of the effector functions of mTOR. Strikingly, the loss of S6k1 in t...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD014832 | Pride
S6k1 Tsc1 Kidney Phosphoproteome Mtor 
ProteomicsmTOR orchestrates sequential phases of ependymal cell differentiation by acting on their alternative cell cycle and centrosomal proteins
Ependymal cells are multiciliated cells lining the brain ventricles, which arise from the differentiation of progenitor cells through the phases of centriole amplification, growth and disengagement phases. Since these commitment phases are accompanied by the sharp up-regulation of mTOR complex 1 act...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-14 | PXD060982 | Pride
Cytoskeleton Ciliogenesis Differentiation Mtor Cell cycle 
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
MetabolomicsLipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations an...
2019-01-07 | MTBLS750 | MetaboLights
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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