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ProteomicsChronic Midazolam Exposure on Neonates and Long-Term Neurodevelopment
About 1 in 10 U.S. newborns are born preterm and often require sedation, which may pose long-term neurodevelopmental risks. This study examined the effects of chronic exposure to midazolam (MDZ), a sedative commonly used in NICUs, using a rodent model. Researchers assessed physical, molecular, bioch...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-27 | PXD062940 | Pride
Midazolam Neurodevelopment 
ProteomicsEarly life exposure to deltamethrin impairs synaptic function by altering the brain derived extracellular vesicle proteome
Pyrethroid pesticides, widely used in agriculture and households, have been associated with neurodevelopmental disorders including attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). While behavioral effects of pyrethroid exposure have been previously reported, the un...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-24 | PXD052521 | Pride
Neurodevelopment Hippocampus Pyrethroid Hebbian plasticity Exosome 
ProteomicsChronic Perinatal Oxycodone Exposure Alters Placental EV Proteome and Fetal Cardiomyopathy-Linked Pathways
The rising prevalence of opioid use during pregnancy poses serious public health concerns, yet the molecular mechanisms by which opioids such as oxycodone impact fetal development remain poorly understood. This study investigates the effects of chronic perinatal oxycodone exposure on the composition...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD065451 | Pride
Ev biomarkers Oxycodone Perinatal exposure Cardiomyopathy Placental signaling Proteomics Fetal development Extracellular vesicles (evs) 
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