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ProteomicsBacterial outer membrane protein prevents enteric Salmonella infection
Probiotics have become promising strategies for treating intestinal barrier dysfunction. However, the mechanisms by which probiotic bacteria interact with host cells to elicit beneficial effects remain unclear. Herein, we demonstrate that administration of E. coli Nissle 1917 (EcN) before Salmonella...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. STm1 Homo sapiens (Human) Escherichia coli 
2026-03-10 | PXD068469 | Pride
Host-microbe interaction Salmonella typhimurium Probiotics Gut-on chip E. coli nissle 1917 
ProteomicsMicroglia cell with light treatment
Explore the protein molecular mechanism of physiological changes in microglia treated with optogenetic technology under light treatment.
ORGANISM(S): Mus musculus (Mouse) 
2024-01-08 | PXD046508 | Pride
Optogenetic Microglia Light treatment 
ProteomicsActivity-Based Metaproteomics Driven Discovery and Enzymological Characterization of Novel α-Galactosidases in the Gut Microbiome
The gut microbiota is an essential contributor to human health and disease and offers an extensive resource of enzymes. Although functional metagenomics methods could predict a correlation between enzyme abundance and functional activity, many enzymes in the microbiome still remain uncharacterized. ...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-03 | PXD046454 | Pride
Α-galactosidases Mus musculus Metaproteomics Activity-based probe Gut microbiome 
ProteomicsA noncanonical role of roX RNAs in autosomal epigenetic repression
Long noncoding RNAs known as roX (RNA on X) are crucial for male development in Drosophila, as their loss leads to male lethality from the late larval stages. While roX RNAs are recognized for their role in sex-chromosome dosage compensation, ensuring balanced expression of X-linked genes in both se...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-11-14 | PXD047183 | Pride
Chirp-ms Polycomb repressive complexes Long noncoding rnas Rox 
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