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TranscriptomicsSensing Cardiac Electrical Activity with a Cardiomyocyte Targeted Optogenetic Voltage Indicator
Rationale: Monitoring and controlling cardiomyocyte activity with optogenetic tools offers exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage indicators may be particularly attractive for minimal invasive and repeated assessments of cardiac ...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-69190 | biostudies-arrayexpress
MetabolomicsMetabolomics dataset of optogenetic axon regenerative mouse model post optic nerve crush
Not available
ORGANISM(S): Mus musculus 
ST002111 | MetabolomicsWorkbench
TranscriptomicsOptogenetic manipulation of BMP signalling to drive chondrogenic differentiation of hPSCs
Optogenetics is a rapidly advancing technology that combines photochemical, optical and synthetic biology techniques to control cellular behaviour and physiology. Combining sensitive light responsive optogenetic intervention tools with human pluripotent stem cell differentiation models has the poten...
ORGANISM(S): Homo sapiens 
2023-11-09 | E-MTAB-13377 | biostudies-arrayexpress
ProteomicsChronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer’s disease-like pathology
Neuronal overexcitability can disrupt synapse formation and strength and elicit synaptic changes which in turn give rise to neuronal hyperactivity, and eventually overall abnormal neural circuit processing. Such network disruption impairs neuronal function and survival, resulting in the onset of neu...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-01 | PXD044437 | Pride
Neuronal hyperactivity  hippocampus  optogenetics  stable step function opsin (ssfo)  proteomics  alzheimer’s disease  neurodegeneration 
GenomicsOptogenetic neural stem cells microarray
Optogenetic neural stem cells microarray
PRJNA417074 | ENA
ProteomicsDirected Differentiation of Human iPSCs into Mesenchymal Lineages by Optogenetic Control of TGF-β Signaling
For chondrogenic studies of optogenetically activated TGF-β signaling, optogenetic human iPSC-derived MSCs were encapsulated in hydrogels (20 million cells/mL of 2% agarose hydrogel). Groups received either no soluble TGF-β or optogenetic stimulation, or soluble TGF-β3 alone, or optogenetic stimulat...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040232 | Pride
Human Ipsc Chondrogenesis Hydrogel Agarose 
GenomicsDevelopmentally-inspired budding morphogenesis by optogenetic receptor tyrosine kinase signaling
Developmentally-inspired budding morphogenesis by optogenetic receptor tyrosine kinase signaling
PRJNA1447937 | ENA
GenomicsEffects of optogenetic and chemogenetic LC activation on the hippocampal transcriptome
Effects of optogenetic and chemogenetic LC activation on the hippocampal transcriptome
PRJNA903150 | ENA
TranscriptomicsFunctional Connection with Cardiac Tissues Confers Maturation Phenotypes in hPSC-Derived PHOX2B::GFP Expressing Sympathetic Neurons
Neurons derived from human pluripotent stem cells (hPSCs) are a remarkable tool for modeling human neural development and diseases. However, it remains largely unknown whether the hPSC-derived neurons can be functionally coupled with their target tissues in vitro, which is essential for understandin...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-80689 | biostudies-arrayexpress
ProteomicsMicroglia cell with light treatment
Explore the protein molecular mechanism of physiological changes in microglia treated with optogenetic technology under light treatment.
ORGANISM(S): Mus musculus (Mouse) 
2024-01-08 | PXD046508 | Pride
Optogenetic Microglia Light treatment 
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