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Lysine malonylation is an evolutionarily conserved PTM from bacteria to mammals and involves malonyl-coenzyme (CoA) as a cofactor. Since the malonyl group has an acidic carboxylic group under physiological pH, malonylated lysine is negatively charged, which might impact on protein function and enzym...
ORGANISM(S): Streptococcus mutans UA159 
2022-11-17 | PXD038045 | Pride
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
The N-terminal three zinc finger motifs of PARP1 are evolutionarily conserved in multicellular organism。However, during apoptosis, human PARP1 is mainly cleaved by caspase 3 at D214. As a result, the truncated PARP1 loses two N-terminal zinc finger motifs and only contains the third zinc finger moti...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD018691 | Pride
The aim of this project was to identify the proteins participating in assemble of supramolecular active complex containing Nav1.7 and Nav1.8 in dorsal root ganglia (DRG) of mice with nerve injury 6 weeks. DRG and spinal dorsal horn (SDH) tissues were collected from spared nerve injury mice and sham-...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-29 | PXD039251 | Pride
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