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Viruses grab the host translation machinery to facilitate their replication by disturbing the host translation. SARS-CoV-2 nsp14 was known to inhibit host translation, yet the mechanistic details are still obscure. In this study, we report that nsp14 can elevate stress granules (SG) formation in a N...
ORGANISM(S): Homo sapiens (Human) 
2026-02-06 | PXD060757 | Pride
Viruses grab the host translation machinery to facilitate their replication by disturbing the host translation. SARS-CoV-2 nsp14 was known to inhibit host translation, yet the mechanistic details are still obscure. In this study, we report that nsp14 can elevate stress granules (SG) formation in a N...
ORGANISM(S): Homo sapiens (Human) 
2026-02-06 | PXD060759 | Pride
1 million MDAMB231 cells were seeded in 6-well plates. On the following day, MBAMB231 cells were treated in triplicates with DMSO, LD4172 (100 nM) or LD4172-NC (100 nM) for 6 hours. Cells were washed with ice-cold PBS three times. The cell pellets were lysed, reduced, alkylated, and digested by Easy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-07 | MSV000092377 | MassIVE
1 million MDAMB231 cells were seeded in 6-well plates. On the following day, MBAMB231 cells were treated in triplicates with DMSO, LD4172 (100 nM) or LD4172-NC (100 nM) for 6 hours. Cells were washed with ice-cold PBS three times. The cell pellets were lysed, reduced, alkylated, and digested by Easy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-05 | MSV000092348 | MassIVE
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