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ProteomicsDe-2-hydroxyisobutyrylation of clusterin attenuates neuropathology and memory deficits in an Alzheimer's disease mouse model
Backgroud Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder for which there is currently no cure, representing a serious clinical challenge. Lysine 2-hydroxyisobutyrylation (Khib) is a newly discovered post-translational modification that has been found to be wid...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-04 | PXD066261 | Pride
Clusterin Adeno-associated viruse 2-hydroxyisobutyrylation Post-translational modification Alzheimer's disease 
UnknownSpatial Distributions, Sources, Potential Risks of Multi-Trace Metal/Metalloids in Street Dusts from Barbican Downtown Embracing by Xi'an Ancient City Wall (NW, China).
Not available
S-EPMC6727082 | biostudies-literature
UnknownGenotype-Guided Dosing of Warfarin in Chinese Adults: A Multicenter Randomized Clinical Trial.
Not available
S-EPMC7439928 | biostudies-literature
Proteomicsmouse hippocampus 4D label free proteomic
Proteomic analysis of hippocampal tissues in control and surgery groups of mice was conducted to investigate the effects of surgery on mice at the protein expression level. The findings aim to provide insights into potential mechanisms underlying cognitive impairment following surgery.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD054165 | Pride
Mouse Hippocampus Proteomic 
UnknownNab-paclitaxel plus cisplatin versus gemcitabine plus cisplatin as first-line treatment in advanced biliary tract cancer: results of a multicentre, randomised, phase II trial.
Not available
S-EPMC12357391 | biostudies-literature
ProteomicsCAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies
HIV-1 latency is a major obstacle to achieve a functional cure for AIDS. To eradicate the viral reservoir, one of the strategies is to specifically reactivate HIV-1-infected cells and followed by elimination with potent immune surveillance. However, present latency-reversing agents (LRAs) are quite ...
ORGANISM(S): Homo Sapiens 
2021-02-09 | PXD024172 |
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