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UnknownCharacterization of GMPP from Dendrobium huoshanense yielding GDP-D-mannose.
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S-EPMC7988358 | biostudies-literature
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
GenomicsNovel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [ChIP-Seq]
Regulatory T (Treg) cells characterized by expression of the transcription factor forkhead box P3 (Foxp3) maintain immune homeostasis by suppressing self-destructive immune responses1-4. Foxp3 operates as a late acting differentiation factor controlling Treg cell homeostasis and function5, whereas ...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-40656 | biostudies-arrayexpress
MetabolomicsElevated temperature accelerates leaf senescence and promotes leaf nitrogen transport to improve rice grain protein synthesis
Elevated temperatures during grain filling severely constrain rice yield and quality. Although additional nitrogen can mitigate the adverse effects of elevated temperature, both factors increase grain protein content, and the underlying physiological mechanisms remain poorly understood. Here, we con...
2026-06-17 | MTBLS14777 | MetaboLights
ProteomicsHierarchical Helical Carbon Nanotube Fibre as a Bone Integrating ACL Replacement
Hierarchically assembled helical fiber integrates effectively with bones
ORGANISM(S): Oryctolagus Cuniculus Homo Sapiens 
2023-03-17 | PXD032128 |
ProteomicsA novel protective microbial metabolite against HIRI in mice
The potential underlying mechanism was via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and HDAC inhibition in macrophages
ORGANISM(S): Mus Musculus 
2020-08-30 | PXD021195 |
ProteomicsMuscular lactate modulates phase transition-driven lactate body secretion to induce liver fibrosis during long-term overtraining
Exercise, as the fundamental therapy for metabolic diseases, often exhibits a dose-dependent fashion. However, the adverse effects of overtraining and underlying mechanisms remain unclear. Here, we show that long-term overtraining induces hepatic fibrosis in humans and mice. Mechanistically, excessi...
ORGANISM(S): Mus Musculus 
2024-05-21 | PXD052424 |
ProteomicsNanoliposuction recycles senescent cell lipids for lubrication
This study aims to systematically profile membrane protein alterations associated with chondrocyte senescence, in order to identify surface markers specifically upregulated in aged cartilage. We established two in vitro models by treating primary chondrocytes with IL-1β or bleomycin, and one in vivo...
ORGANISM(S): Mus Musculus 
2025-06-10 | PXD064867 |
ProteomicsPBP inactivation and OXA treatment resulted in altered protein compositions of Staphylococcal membrane vesicles
The engineered Staphylococcus aureus strain RN4220Δagr/EDⅢ was treated with 1/4 MIC of Oxacillin (OXA), or used to construct pbp3 and pbp4 gene mutant strain. Then, the membrane vesicles (MVs) of parent strain (ΔagrMVs), OXA-treated strain (Δagr/OXAMVs), and pbp3/pbp4 mutants (Δagr/OXAMVs) were harv...
ORGANISM(S): Staphylococcus Aureus Subsp. Aureus Rn4220 
2024-10-21 | PXD057038 |
ProteomicsRisk stratification of thyroid papillary cancer based on proteomics and machine learning
Papillary thyroid cancer (PTC) is the most common type of thyroid carcinoma accounting for 85%. Most PTCs have a low risk of recurrence and metastasizing and not all low-risk PTCs need immediate surgery. However, cases are often recognized as low-risk only after surgery. Our study aimed to find a pr...
ORGANISM(S): Homo Sapiens 
2024-03-13 | PXD050577 |
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