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ProteomicsStructure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed...
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061425 |
ProteomicsImmunopeptidomics-guided warehouse design for peptide-based immunotherapy in chronic lymphocytic leukemia
In recent years the clinical success of T cell-based immunotherapy approaches has revolutionized treatment of solid tumors and hematological malignancies. However, still some patients do not respond to available therapies at all, others for limited time only. A promising low side-effect approach is ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024871 | Pride
Cll Hla Peptide warehouse Immunopeptidome 
ProteomicsIonmob: A Python Package for Prediction of Peptide Collisional Cross-Section Values
Motivation: Including ion mobility separation (IMS) into mass spectrometry proteomics experiments is useful to improve coverage and throughput. Many IMS devices enable linking experimentally derived mobility of an ion to its collisional cross-section (CCS), a highly reproducible physicochemical pro...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2023-09-21 | PXD043026 | JPOST Repository
ProteomicsIn situ synthesis of peptide microarrays - shadow mask design [3]
In this paper several computer programs were used to simulate in situ synthesis of peptides using shadow masks and BOC synthesis. The peptides were designed to be random, or pseudo-random, but fulfill requirements of immunosignaturing. This file contains data from actual 330,000 peptide arrays tha...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50571 | biostudies-arrayexpress
ProteomicsIn situ synthesis of peptide microarrays - shadow mask design [2]
An experiment was designed to use a computer program to create lithography masks using a pseudo-random pattern generator. The data in this file are results from immunosignaturing 8 different monoclonals using a 10,000 peptide random-sequence microarray. Peptides were synthesized by Sigma Aldrich, ...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50044 | biostudies-arrayexpress
GenomicsPeptide design by optimization on a data-parameterized protein interaction landscape
Peptide design by optimization on a data-parameterized protein interaction landscape
PRJNA484708 | ENA
ProteomicsIn situ synthesis of peptide microarrays - shadow mask design [1]
A computer program was used to create random amino acid sequences based on and restricted by physical shadow masks which will be used for lithography-based synthesis of peptides. The output from this algorithm was used to create peptides that were synthesized by Sigma Aldrich, and printed onto glas...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-49217 | biostudies-arrayexpress
ProteomicsWarehouse-based, immunopeptidome-guided design of personalised peptide vaccines shows feasibility in clinical trial evaluation in CLL patients
Cancer peptide vaccination represents a promising therapeutic approach, but has been hampered by lack of suitable antigens and restricted applicability due to different HLA backgrounds of individual patients. We here introduce a novel warehouse-based concept for composition of personalized peptide v...
ORGANISM(S): Homo sapiens (Human) 
2024-11-08 | PXD054248 | Pride
Human Leukemia Vaccine Cll Warehouse Lc-ms/ms 
ProteomicsRational Design of High Affinity Peptides Validates Histone Chaperone ASF1 as a New Epigenetic Target in Cancer
Starting from the structure of the human ASF1-histone complex, we developed a rational design strategy combining epitope tethering and optimization of interface contacts to identify a potent peptide inhibitor with a dissociation constant of 3 nM. LC-MS/MS was used to identify in vivo targets of the ...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD013279 | Pride
Peptide design Inhibitory peptides Histone chaperone 
UnknownDesign and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications.
Not available
S-EPMC4027376 | biostudies-literature
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