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ProteomicsImmunopeptidomics-guided warehouse design for peptide-based immunotherapy in chronic lymphocytic leukemia
In recent years the clinical success of T cell-based immunotherapy approaches has revolutionized treatment of solid tumors and hematological malignancies. However, still some patients do not respond to available therapies at all, others for limited time only. A promising low side-effect approach is ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024871 | Pride
Cll Hla Peptide warehouse Immunopeptidome 
ProteomicsWarehouse-based, immunopeptidome-guided design of personalised peptide vaccines shows feasibility in clinical trial evaluation in CLL patients
Cancer peptide vaccination represents a promising therapeutic approach, but has been hampered by lack of suitable antigens and restricted applicability due to different HLA backgrounds of individual patients. We here introduce a novel warehouse-based concept for composition of personalized peptide v...
ORGANISM(S): Homo sapiens (Human) 
2024-11-08 | PXD054248 | Pride
Human Leukemia Vaccine Cll Warehouse Lc-ms/ms 
ProteomicsPhase I study of immunopeptidome-guided personalized multi-peptide vaccines in chronic lymphocytic leukemia patients under BTK-inhibitor-based regimes
Cancer peptide vaccines hold promise as therapeutic approach, but their effectiveness has been hampered by lack of suitable antigens and the variability of HLA backgrounds among patients, which restricts their applicability.. We here introduce a novel warehouse concept for the construction of person...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD059004 | Pride
Human Cll Immunopeptidomics Lc-ms/ms 
UnknownWarehouse-based, immunopeptidome-guided design of personalised peptide vaccines shows feasibility in clinical trial evaluation in CLL patients.
Not available
S-EPMC11628388 | biostudies-literature
UnknownImmunopeptidomics-Guided Warehouse Design for Peptide-Based Immunotherapy in Chronic Lymphocytic Leukemia.
Not available
S-EPMC8297687 | biostudies-literature
TranscriptomicsImmunopeptidome-guided personalized peptide vaccines induce potent T cell response in chronic lymphocytic leukemia
T cell immunity is central for the control of malignant disease. Chronic lymphocytic leukemia (CLL) lacks mutation-derived T cell neoantigens, yet harbours frequent tumor-associated antigens as targets for therapeutic vaccine design. iVAC-XS15-CLL01 is a warehouse-based personalized muli-peptide vac...
ORGANISM(S): Homo sapiens 
2026-08-01 | GSE305113 | GEO
GenomicsImmunopeptidome-guided personalized peptide vaccines induce potent T cell response in chronic lymphocytic leukemia
Immunopeptidome-guided personalized peptide vaccines induce potent T cell response in chronic lymphocytic leukemia
PRJNA1304449 | ENA
UnknownA randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma.
Not available
S-EPMC6380422 | biostudies-literature
UnknownIdentification of biomarkers for personalized peptide vaccination in 2,588 cancer patients.
Not available
S-EPMC7170040 | biostudies-literature
ProteomicsHuman Arthritic Synovial Fluid LC-MS/MS
In the present study, synovial fluid (SF) samples from inflammatory arthritis (IA) patients were subjected to a label-free, mass spectrometry-based approach for the identification and quantification of IA-specific proteins and peptides. The discovery-phase project generated a warehouse of proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011872 | Pride
Synovial fluid Human Arthritis Lc-ms/ms 
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