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GenomicsHepatic perilipin 5 is required for fasting-induced autophagy to prevent fatty acid-induced inflammation
Hepatic perilipin 5 is required for fasting-induced autophagy to prevent fatty acid-induced inflammation
PRJNA588054 | ENA
ProteomicsProtein kinase A phosphorylation of perilipin 5 on serine 155 regulates liver lipolysis via interactions with adipose triglyceride lipase
Perilipin (PLIN) 5 is a lipid droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). We detected phosphorylation on S155, S161 and S163 of recombinant PLIN5 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-11 | PXD021969 | Pride
Lipid droplets Fatty acid Perilipin Lipase Triglycerides Lipid metabolism Phosphorylation 
ProteomicsCardiac perilipin 5 promotes physiological cardioprotective hypertrophy through increased calcium handling and cardiomyocyte contractility
: The adult heart develops hypertrophy to reduce ventricular wall stress and maintain cardiac function in response to an increased workload. Although pathological hypertrophy generally progresses to heart failure, physiological hypertrophy may be cardioprotective. Cardiac-specific overexpression of ...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-20 | PXD035121 | Pride
Perilipin 5  mhc-plin5  physiological hypertrophy  calcium signaling  serca2. 
TranscriptomicsHepatic perilipin 5 is required for fasting-induced autophagy to prevent fatty acid-induced inflammation
Hepatic perilipin 5 is required for fasting-induced autophagy to prevent fatty acid-induced inflammation.
ORGANISM(S): Mus musculus 
2019-11-07 | GSE140024 | GEO
UnknownPNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL.
Not available
S-EPMC9818421 | biostudies-literature
ProteomicsPerilipin 5-mediated lipid droplet-mitochondria coupling determines mitochondrial capacity
Disturbances in lipid homeostasis can cause mitochondrial dysfunction and lipotoxicity requiring tight regulation of intracellular lipid metabolism and fatty acid (FA) flux. Perilipin 5 (PLIN5) decorates intracellular lipid droplets (LD) in oxidative tissues and controls triacylglycerol (TG) turnove...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD028541 | Pride
Mitochondria Lipid droplet Fatty acid metabolism Plin5 
TranscriptomicsSpatial transcriptomic profiling of quadriceps muscles from mice fed either standard diet or high-fat diet for 20 weeks
Intermuscular adipose tissue (IMAT) accumulation within skeletal muscle is associated with cardiometabolic disease, yet its spatial organization and molecular drivers remain poorly characterized. To map IMAT expansion within the quadriceps muscle architecture, spatial transcriptomics was performed o...
ORGANISM(S): Mus musculus 
2026-07-12 | E-MTAB-17271 | biostudies-arrayexpress
ProteomicsIdiopathic focal segmental glomerulosclerosis plasmas increase lipid droplet formation and perilipin-2 expression in human podocytes
Background: Many patients with idiopathic focal segmental glomerulosclerosis (FSGS) develop recurrence of proteinuria after kidney transplantation. Several circulating permeability factors (CPFs) responsible for recurrence have been suggested, but there is no consensus about the identity of CPFs in ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-22 | PXD028536 | Pride
Circulating permeability factor Podocytes Lipid droplets Perilipin-2 Idiopathic focal segmental glomerulosclerosis (fsgs) 
UnknownNuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function.
Not available
S-EPMC4999519 | biostudies-literature
UnknownCardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction.
Not available
S-EPMC3606001 | biostudies-literature
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