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TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in Danio rerio during optic nerve regeneration
To gain a better understanding of the factors necessary for successful CNS regeneration, a temporal analysis of the changes in gene expression in the eye caused by optic nerve injury was conducted. Dual color oligonucleotide microarrays were used to compare total RNA harvested from the eyes of sham...
ORGANISM(S): Danio rerio 
2010-05-16 | E-GEOD-17854 | biostudies-arrayexpress
ProteomicsComparative proteomics analysis of growth-primed adult dorsal root ganglia reveals key molecular mediators for peripheral nerve regeneration
Peripheral nerve injuries due to physical insults or chronic diseases are quite common, yet no pharmacological therapies are available for the effective repair of injured nerves. The slow growth rate of adult nerves and insufficient access to growth factors pose major hurdles in timely reinnervating...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-06 | PXD031927 | Pride
Spinal root Rat Comparative proteomics Sciatic nerve Drgs Sensory neuron of dorsal root ganglion Nerve regeneration 
ProteomicsRat motor and sensory nerve LC-MSMS
Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. It is important to fully understand the cellular and molecular basis underlying the specificity of peripheral nerve regeneration, which means the achieving of respective ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-12-10 | PXD022097 | Pride
Lc-msms Sensory nerve Rat Motor nerve Peripheral nerve injury 
ProteomicsRac1 inhibition prevents cytoskeleton dysfunction and axonal degeneration in Transthyretin Amyloid Polyneuropathy
Transthyretin Amyloid Polyneuropathy (ATTR-PN) is characterized by the deposition of amyloidogenic TTR particularly in dorsal root ganglia (DRG) and peripheral nerve axons leading to a sensory axonopathy. Here, we investigated the role of cytoskeleton alterations in peripheral axons from an ATTR-PN ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-10 | PXD054291 | Pride
Transthyretin  axonopathy  transthyretin amyloid polyneuropathy  cytoskeleton  microtubule dynamics  actin  axonal transport  peripheral nervous system  rac1 
TranscriptomicsTimecourse expression data from sciatic nerve distal stump of C57BL/6 and C57BL/6 OlaHsd-Wlds mice.
Wallerian degeneration (WD) involves the fragmentation of axonal segments disconnected from their cell bodies, segmentation of the myelin sheath, and removal of debris by Schwann cells and immune cells. The removal and downregulation of myelin-associated inhibitors of axonal regeneration and synthes...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-22291 | biostudies-arrayexpress
ProteomicsA specific matrisome composition drives a regeneration program in peripheral axonal neuropathies
Understanding the multiple mechanisms underlying peripheral nerve regeneration in humans is crucial for developing effective therapies for peripheral axonal neuropathies. Although in vitro and in vivo studies have provided significant insights, human studies exploring the extracellular matrix (ECM) ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD068740 | Pride
Extracellular matrix remodelling Peripheral nerve regeneration Protein modulation. Axonal neuropathy 
TranscriptomicsDifferential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush
Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-17117 | biostudies-arrayexpress
TranscriptomicsRobust axonal regeneration occurs in the injured CAST/Ei mouse central nervous system
Axon regeneration in the central nervous system (CNS) requires reactivating injured neurons’ intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on C...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-67130 | biostudies-arrayexpress
TranscriptomicsGene expression signatures following nerve injury in a rat model (0h-9h)
We used microarrays to distinguish the gene expression differences among different time points after injury. We generated proximal sciatic nerve (SN) tissues (0.5cm) at 0h, 0.5h, 1h, 3h, 6h and 9h after sciatic nerve resection.
ORGANISM(S): Rattus norvegicus 
2012-12-20 | E-GEOD-33175 | biostudies-arrayexpress
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