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TranscriptomicsA protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2
The association between hyper-inflammatory states and numerous diseases is widely recognized, but our understanding of the molecular strategies that have evolved to prevent uncontrolled activation of inflammatory responses remains incomplete. Here, we report a critical, non-transcriptional role of G...
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-35197 | biostudies-arrayexpress
ProteomicsInhibition of MUL1-mediated ubiquitination promotes mitochondria-associated translation
G-Protein Pathway Suppressor 2 (GPS2) is an inhibitor of non-proteolytic ubiquitination mediated by the E2 ubiquitin-conjugating enzyme Ubc13. Previous studies have associated GPS2-mediated restriction of K63 ubiquitination with the regulation of insulin signaling, inflammatory responses and mitocho...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD030187 | Pride
Lc-msmubiquitin I.e. human Pabpc Mitochondria stress response (msr)s Plasma Mitochondria Mul1 Gps2 Liver 
UnknownThe co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.
Not available
S-EPMC3656868 | biostudies-literature
UnknownTBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.
Not available
S-EPMC2364611 | biostudies-literature
UnknownGPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARγ.
Not available
S-EPMC4104678 | biostudies-literature
UnknownThe Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet.
Not available
S-EPMC7012923 | biostudies-literature
UnknownNeuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins.
Not available
S-EPMC8932523 | biostudies-literature
UnknownMitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation.
Not available
S-EPMC6022402 | biostudies-literature
UnknownGPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity.
Not available
S-EPMC9922684 | biostudies-literature
UnknownA SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
Not available
S-EPMC1464798 | biostudies-literature
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