Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse Perk wild-type and knockout liver perfused without or with 2,5-di-tert-butylhydroquinone
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11684 | biostudies-arrayexpress
TranscriptomicsThe eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
Disruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER stress and elicit an unfolded protein response (UPR) that involves translational and transcriptional changes in gene expression aimed at expanding the ER processing capacity and alleviating cellular injury. Three ER ...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-29929 | biostudies-arrayexpress
TranscriptomicsExpression data from menadione, PERK inhibitor, or control-treated HMLE-shGFP and HMLE-Twist human mammary epithelial cells
Malignant carcinomas that recur following therapy are typically de-differentiated and multi-drug resistant (MDR). De-differentiated cancer cells acquire MDR by upregulating reactive oxygen species (ROS)-scavenging enzymes and drug efflux pumps, but how these genes are upregulated in response to de-d...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-59780 | biostudies-arrayexpress
ProteomicsProteomic analysis on human islet with treatment of a PERK inhibitor
Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD066613 | Pride
Tmt Perk inhibitor Islet 
ProteomicsDIA-based Proteomic analysis of human islets with treatment of a PERK inhibitor
Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD074587 | Pride
Human Islets Dia Perk inhibitor 
TranscriptomicsTranscription profiling of mouse liver to assess the translational response following activation of GCN2 versus PERK - super series
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11685 | biostudies-arrayexpress
ProteomicsPERK protein kinase facilitates keratinocyte collective cell migration by engagement with cell adhesion molecules independent of its kinase activity
Proximity labeling experiments (BioID) were performed on Human NTERT keratinocytes depleted of PERK (EIF2AK3, PERK-KO) re-expressing a WT PERK containing a C-terminal UltraID tag. PERK-KO and PERKUltraID cells were treated with differentiation medium containing 50 uM of exogenous Biotin for 6 h, wa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-11 | MSV000098126 | MassIVE
UnknownStructural determinants of PERK inhibitor potency and selectivity.
Not available
S-EPMC3058854 | biostudies-literature
UnknownCharacterization of a PERK Kinase Inhibitor with Anti-Myeloma Activity.
Not available
S-EPMC7601861 | biostudies-literature
UnknownDiscovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.
Not available
S-EPMC4027568 | biostudies-literature
Sort   by:  
 Page size