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TranscriptomicsmRNA expression data of 62 human medulloblastoma tumors
To identify molecular subtypes of medulloblastoma we have profiled a series of 62 medulloblastoma tumors. Unsupervised hierarchical cluster analysis of these data identified 5 distinct molecular subtypes. Manuscript submitted. Title: Identification of medulloblastoma subtypes with distinct genetic p...
ORGANISM(S): Homo sapiens 
2008-09-02 | E-GEOD-10327 | biostudies-arrayexpress
UnknownmRNA expression data of 62 human medulloblastoma tumors
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-10327 | biostudies-other
ProteomicsExternal and intrinsic mechanical stress restricts pheromone signaling by direct phosphorylation of the Ste5 scaffold by Pkc1
Ste5 and Far1 function as prototypical scaffold proteins activating a MAP-kinase cascade and polarizing yeast cells in response to pheromones. Here we show that Pkc1-dependent phosphorylation of conserved serine residues in their RING-H2 domains down-regulates pheromone induced signaling upon mechan...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-06-17 | PXD004657 | Pride
Yeast Saccharomyces cerevisiae Scaffold Mapk Ste5 Far1 
ProteomicsLC-MSMS with isobaric tagging on Flag-coimmunoprecipitation eluates from Flag-Pgrmc1 and Y113F Flag-Pgrmc1 expressing Pgrmc1 KO mouse liver membranes
Progesterone receptor membrane component 1 (PGRMC1) is a heme binding protein implicated in a wide range of cellular functions. Our previous studies showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and promotes activity of these enzymes. Recently, the paralog PGRMC2 was show...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028284 | Pride
Lc-msms Mouse Tmt Co-immunoprecipitation Y113f flag-pgrmc1 Bound Membrane Pgrmc1 Flag-pgrmc1 Liver Eluate Isobaric tag 
ProteomicsLC-MSMS with isobaric tagging of Pgrmc1 KO mouse liver membranes expressing Flag-Pgrmc1 or Y113F Flag-Pgrmc1
Progesterone receptor membrane component 1 (PGRMC1) is a heme binding protein implicated in a wide range of cellular functions. Our previous studies showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and promotes activity of these enzymes. Recently, the paralog PGRMC2 was show...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD028288 | Pride
Lc-msms Mouse Tmt Y113f flag-pgrmc1 Membrane Pgrmc1 Flag-pgrmc1 Liver Isobaric tag 
TranscriptomicsExpression profiling of Moraxella catarrhalis RH4 during in vitro growth in brain heart infusion (BHI) medium
Transcriptome analysis of M. catarrhalis RH4 predicted coding sequences and clustered regularly interspaced short palindromic repeats (CRISPRs) regions. The results described in this study are further discussed in De Vries, S.P.W., van Hijum, S.A.F.T., Schueler, W., Riesbeck, K., Hays, J.P., Hermans...
ORGANISM(S): Moraxella catarrhalis RH4 
2010-05-07 | E-GEOD-21632 | biostudies-arrayexpress
TranscriptomicsGene expression variation in African and European populations of Drosophila melanogaster
Background: Differences in levels of gene expression among individuals are an important source of phenotypic variation within populations. Recent microarray studies have revealed that expression variation is abundant in many species, including Drosophila melanogaster. However, previous expression su...
ORGANISM(S): Drosophila melanogaster 
2008-01-20 | E-GEOD-8843 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chromic myeloid leukemia (CML) patients treated second-line with imatinib after failure of an interferon-alpha based therapy to identify genes with predictive value for primary cytogenetic outcome to imatinib
Identification of genes in CML patients with predictive value for their primary cytogenetic outcome to imatinib. All samples analyzed were taken just before the start of imatinib treatment. Leukemic patients were treated second-line with imatinib after failure of an interferon-alpha based therapy (f...
ORGANISM(S): Homo sapiens 
2006-05-31 | E-MEXP-433 | biostudies-arrayexpress
UnknownIdentification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study.
Not available
S-EPMC3595425 | biostudies-literature
UnknownInherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Not available
S-EPMC4302212 | biostudies-literature
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