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TranscriptomicsGene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of EZH2
We studied transcriptional changes by Affymetrix human microarrays in 2 DLBCL cell lines as a result of shRNA mediated knockdown of EZH2. In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-41239 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of transgenic mice (tTA/IkappaBalpha-AA) treated with doxycycline (DOX), which represses expression of the transgenic IkappaBalpha
double transgenic mice (tTA/IkappaBalpha-AA) were treated with doxycycline (DOX), which represses expression of the transgenic IkappaBalpha. Double transgenic mice without Dox-treatment overexpress the transdominant IkappaBalpha, which represses NFkappaB activation.
ORGANISM(S): Mus musculus 
2006-05-10 | E-MEXP-358 | biostudies-arrayexpress
Transcriptomicscis sequence effects on gene expression
Sequence and transcriptional variability within and between individuals are typically studied independently. The joint analysis of sequence and gene expression variation provides insight into biological mechanisms that underlie gene regulation and function. We investigated the role of sequence varia...
ORGANISM(S): Homo sapiens 
2008-04-09 | E-GEOD-8394 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Physcomitrella patens leaflet timeseries
Transcription profiling of Physcomitrella patens leaflet timeseries
ORGANISM(S): Physcomitrella patens 
2013-02-18 | E-MTAB-915 | biostudies-arrayexpress
MetabolomicsPREDICT: untargeted metabolomic profiling in a Brassica napus (canola) breeding population by GC-MS

Genome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibriu...

2023-11-20 | MTBLS8056 | MetaboLights
UnknownHuman papillomavirus and rising oropharyngeal cancer incidence in the United States.
Not available
S-EPMC3221528 | biostudies-literature
TranscriptomicsDetecting novel genes with sparse arrays
Species-specific genes play an important role in defining the phenotype of an organism. However, current gene prediction methods can only efficiently find genes that share features such as sequence similarity or general sequence characteristics with previously known genes. Novel sequencing methods a...
ORGANISM(S): Hypocrea jecorina 
2010-08-12 | E-GEOD-12960 | biostudies-arrayexpress
TranscriptomicsIdentification of Hfq bound RNA by co-immunoprecipitation and RNA-sequencing
Co-immunoprecipitation with endogenous Hfq3xFlag in exponential, stationary, non-induced and virulence induced conditions, followed by RNA-sequencing, revealed 1697 mRNAs and 208 ncRNAs associated with Hfq. We identified 56 new ncRNAs and validated 3 Hfq-dependent trans sRNAs on by Northern blot ana...
ORGANISM(S): Agrobacterium tumefaciens 
2014-12-04 | E-GEOD-59123 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor
We studied transcriptional changes by Affymetrix human microarrays in DLBCL cell lines as a result of treatment with GSK126, a potent, highly-selective, SAM-competitive, small molecule inhibitor of EZH2 In eukaryotes, epigenetic post-translational modification of histones is critical for regulation ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40971 | biostudies-arrayexpress
ProteomicsA monoclonal anti-HMGB1 antibody attenuates neurodegeneration in an experimental animal model of glaucoma
Neuroinflammation is a crucial process for the loss of retinal ganglion cells (RGC), a major characteristic of glaucoma. High expression of high mobility group box protein 1 (HMGB1) plays a detrimental role in inflammatory processes and is elevated in the retinas of glaucoma patients. Therefore, thi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD031987 | Pride
Glaucoma Discovery proteomics Neuroprotection Microarray Antibodies Neurodegeneration Animal model 
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