Sort   by:  
 Page size 
UnknownMIER2/PGC1A elicits sunitinib resistance via lipid metabolism in renal cell carcinoma.
Not available
S-EPMC11976417 | biostudies-literature
ProteomicsThe role of IRAKM in IL-1β-treated adipocytes
Toll-like receptors/Interleukin-1 receptor (IL-1R) signaling plays an important role in High-fat diet (HFD)-induced adipose tissue dysfunction contributing to obesity-associated metabolic syndromes. Here, we show an unconventional IL-1R-IRAKM (IL-1R-associated kinase M)-Slc25a1 signaling axis in adi...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD031934 | Pride
Irakm Fatty acid synthesis Pgc1a acetylation Adipocytes Slc25a1 
TranscriptomicsPML regulates PPAR signaling and fatty acid oxidation in breast cancer
Cancer cells exhibit an aberrant metabolism which facilitates more efficient production of biomass, and hence tumor growth and progression. The genetic cues modulating this metabolic switch remain largely undetermined, however. Here we identify a metabolic function for PML which reveals an unexpecte...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-39220 | biostudies-arrayexpress
GenomicsPan-HDAC Inhibition Reverses the Warburg Effect and Leads to Metabolic Vulnerabilities
We report the HDAC inhibiton of glioblastoma cells causes histone H3K27 acetylation and leads to upreguated OXPHOS master regulator PGC1a which then leads to an increase in mitochondrial fusion, mitochondrial biogenesis and higher mitochondrial oxygen consumption rate coupled with increased fatty ac...
ORGANISM(S): Homo sapiens 
2020-03-24 | GSE124877 | GEO
ProteomicsPromyelocytic leukemia protein (PML) is a regulator of eNSC differentiation, survival and mitochondrial metabolism.
OThis study identifies the tumor suppressor PML as a regulator of embryonic neural stem cell (eNSC) homeostasis, highlighting its role in their proliferation, differentiation and metabolism. Loss of the promyelocytic leukemia (PML) protein has been previously linked to abnormal proliferation and dif...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD059100 | Pride
Stem cell Ensc Pml 
UnknownIL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice.
Not available
S-EPMC9117277 | biostudies-literature
UnknownA metabolic prosurvival role for PML in breast cancer.
Not available
S-EPMC3433768 | biostudies-literature
GenomicsPan-HDAC Inhibition Reverses the Warburg Effect and Leads to Metabolic Vulnerabilities
Pan-HDAC Inhibition Reverses the Warburg Effect and Leads to Metabolic Vulnerabilities
PRJNA514055 | ENA
TranscriptomicsPML regulates PPAR signaling and fatty acid oxidation in breast cancer
Cancer cells exhibit an aberrant metabolism which facilitates more efficient production of biomass, and hence tumor growth and progression. The genetic cues modulating this metabolic switch remain largely undetermined, however. Here we identify a metabolic function for PML which reveals an unexpecte...
ORGANISM(S): Mus musculus 
2013-01-29 | GSE39220 | GEO
ProteomicsDefective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome
Leigh syndrome (LS) is a severe manifestation of mitochondrial disease in children and is currently incurable. The lack of effective models hampers our understanding of the mechanisms underlying the neuronal pathology of LS. Using patient-derived induced pluripotent stem cells and CRISPR/Cas9 engine...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD019112 | Pride
Mitochondrial disease  leigh syndrome  ipscs  npcs  brain organoids  surf1 
Sort   by:  
 Page size