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GenomicsEvolution and genetic architecture of chromatin accessibility and function in yeast
Chromatin accessibility is an important functional genomics phenotype that influences transcription factor binding and gene expression. Genome-scale technologies allow chromatin accessibility to be mapped with high-resolution, facilitating detailed analyses into the genetic architecture and evolutio...
ORGANISM(S): Saccharomyces cerevisiae x Saccharomyces paradoxus 
2014-06-01 | E-GEOD-55717 | biostudies-arrayexpress
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD047593 | Pride
Degron Protein degradation Cereblon Phase-assisted evolution Molecular glues 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047665 | Pride
Cereblon Phase assisted evolution Molecular glue Imid Protein degradation 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044940 | Pride
Phage Cereblon Evolution Molecular glue Mg-pace Protein degradation 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2026-08-29 | PXD044978 | Pride
Protein degradation Cereblon Evolution Mg-pace Zinc finger Molecular glues 
ProteomicsProteomic Investigation of Evolved Daptomycin-Tolerant MRSA due to Mutation in YycH
Several groups have shown that through evolution experiments, tolerance and resistance evolved rapidly under cyclic antibiotic treatment. In other words, intermittent antibiotic exposure performed in a typical adaptive laboratory evolution (ALE) experiments will “train” the bacteria to become tolera...
ORGANISM(S): Staphylococcus aureus 
2022-07-16 | PXD031078 | Pride
Proteomics Daptomycin Methicillin-resistant s. aureus Adaptive laboratory evolution Tolerance Yych 
UnknownAdvancing Oxygen Evolution Catalysis with Dual-Phase Nickel Sulfide Nanostructures.
Not available
S-EPMC11748485 | biostudies-literature
UnknownSqueezing giant spin states via geometric phase control in cavity-assisted Raman transitions.
Not available
S-EPMC5634490 | biostudies-literature
MetabolomicsModel-guided development of evolutionarily stable yeast chassis for dicarboxylic acids production

Chassis strain suitable for producing multiple compounds is a central concept in synthetic biology. Design of a chassis using computational, first-principle, models is particularly attractive due to the predictability and control it offers, including against phenotype reversal due to adaptive mut...

2021-07-19 | MTBLS2007 | MetaboLights
UnknownMicrowave-Assisted Synthesis of IrNi Electrocatalysts for the Oxygen Evolution Reaction in Acidic Electrolyte.
Not available
S-EPMC12598801 | biostudies-literature
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