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ProteomicsQuantitative interactome analysis of PHD2
To identify novel regulator of EGLN1/PHD2, we performed label-free quantitative interactome analysis. Stable Hela cell lines expressing Flag-tagged PHD2 and control vector were generated. Immunoprecipitation and mass spectrometry analysis were performed to identify novel interactors of PHD2 followed...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014757 | Pride
Egln1 Hypoxia Ubiquitination Phd2 
TranscriptomicsAnalysis of mRNA abundance in the wild-type or Phd2 knockout carotid body and adrenal medulla of mice
The mRNA abundance in the wild-type or Phd2 knockout carotid body and adrenal medulla of mice was analysed by RNA-Seq. For this purpose, mice with tyrosine hydroxylase-restricted inactivation of Phd2 were generated. For the preparation of a single RNA-Seq library, RNA from 10 carotid bodies or adren...
ORGANISM(S): Mus musculus 
2023-08-14 | E-MTAB-13163 | biostudies-arrayexpress
ProteomicsCharacterization of the molecular determinants of MLL3/4 PHD2 and PHD3 (PHD2/3) fingers binding to ASXL2
This submission contains the mass spectrometry files for the manuscript by Yi Zhang et al. that describes the functional characterization of the molecular determinants of MLL3/4 PHD2 and PHD3 (PHD2/3) fingers binding to ASXL2. AP-MS experiments were performed from K562 cells and MS files were acquir...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-20 | MSV000093435 | MassIVE
Genomicsmesendoderm differentiation of WT and PHD2 knockout mESCs (scRNA-seq)
mesendoderm differentiation of WT and PHD2 knockout mESCs (scRNA-seq)
PRJNA1028512 | ENA
GenomicsPHD2 constrains the anti-tumor CD8+ T cell activity
PHD2 constrains the anti-tumor CD8+ T cell activity
PRJNA894180 | ENA
UnknownThermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: computational approaches.
Not available
S-EPMC3471951 | biostudies-literature
Transcriptomicsmesendoderm differentiation of WT and PHD2 knockout mESCs (scRNA-seq)
To study the cell composition and gene expression profile in the mesendoderm differentiation of WT and PHD2 knockout, we performed scRNA-seq on the cells collected from the differentiation of WT and PHD2 knockout AB2.2 mESCs at differentiation day 4. PHD2 knockoutout mESCs were constructed by CRISPR...
ORGANISM(S): Mus musculus 
2024-09-05 | GSE245439 | GEO
UnknownPHD2 safeguards modest mesendoderm development.
Not available
S-EPMC11380689 | biostudies-literature
UnknownCrosslinking-mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2 in Regulating Protein Neddylation.
Not available
S-EPMC11702602 | biostudies-literature
GenomicsA chromatin-linked CPL2–PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing [WGBS]
A chromatin-linked CPL2–PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing [WGBS]
PRJNA1310499 | ENA
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