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ProteomicsHCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication
Human cytomegalovirus (HCMV) is a leading cause of congenital infection and morbidity in immunosuppressed populations. Like all viruses, HCMV is an obligate intracellular parasite that extensively remodels host cellular metabolism to support its replication, yet the precise underlying mechanisms and...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD074057 | Pride
Mrc5 Hcmv Egln1 Egln Adaptaquin Lc-ms/ms 
ProteomicsRepression of EGLN1 activity by SET7-catalyzed methylation
Repression of EGLN1 activity by SET7-catalyzed methylation
ORGANISM(S): Homo Sapiens 
2022-03-08 | PXD032126 |
GenomicsHypoxia-inducible EglN1+ small extracellular vesicles establish an immunosuppressive lung niche for metastatic colonization
MDA-MB-231 EglN1-Flag IP-MS
PRJEB101377 | ENA
TranscriptomicsEffect of EglN1 knockdown on smooth muscle expression
Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more prolonged, ischemic insult. In remote ischemic preconditioning (RIPC), ischemia to one organ protects other organs at a distance. We developed mouse models to ask if inhibition o...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-77789 | biostudies-arrayexpress
TranscriptomicsEffect of EglN1 knockdown on smooth muscle expression
Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more prolonged, ischemic insult. In remote ischemic preconditioning (RIPC), ischemia to one organ protects other organs at a distance. We developed mouse models to ask if inhibition o...
ORGANISM(S): Mus musculus 
2016-02-11 | GSE77789 | GEO
GenomicsOxygen enhances antiviral innate immunity through maintenance of EGLN1-catalysed proline hydroxylation of IRF3
Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalysed proline hydroxylation of IRF3
PRJNA1064164 | ENA
ProteomicsMitochondria EglN1 drivers breast cancer progression by controlling metabolic adatation to hypoxic stress
Hypoxia is a hallmark of solid tumors. Mitochondria play essential roles in cellular adaptation to hypoxia, but the underlying mechanisms are not fully understood. Through mitochondrial proteomic profiling, we find that the prolyl hydroxylase EglN1 accumulates on mitochondria under hypoxia. EglN1 su...
ORGANISM(S): Homo sapiens (Human) 
2023-08-29 | PXD041653 | Pride
T47d normoxia and hyppoxia mitochondria ms 
UnknownEGLN1 (PHD2) role in tumor microenvironment: insights for therapeutic targeting.
Not available
S-EPMC12800280 | biostudies-literature
UnknownEGLN1 inhibition reverses angiogenesis impairment in hyperglycemia by activating autophagy.
Not available
S-EPMC12521508 | biostudies-literature
GenomicsMus musculus strain:C57BL6J
Egln1 tie2 KO in PH
PRJNA304254 | ENA
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