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ModelsLiX2019 - macrophage polarization and tumor cell plasticity
This model is based on: Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment. Abstract: Tumor microenvironments contain multiple cell types interacting among one another via different signaling pathways. Furthermore, both ca...
2019-09-23 | MODEL1909230002 | BioModels
Immuno-oncology 
MetabolomicsIntegrated transcriptome and metabolome dynamics with phenotypic traits reveal regulatory basis of male morphotype differentiation in giant freshwater prawn Macrobrachium rosenbergii

This integrated multi-omics resource delineates the molecular and phenotypic trajectories underlying male morphotype differentiation (Blue Claw [BC], Orange Claw [OC], Small Male [SM]) in macrobrachium rosenbergii during determinative developmental stages (100, 110, and 120 days pos...

2025-08-22 | MTBLS12876 | MetaboLights
MetabolomicsAssessment of phenotypic trait plasticity in the oilseed Camelina sativa using integrated early-stage abiotic stress and field studies

Connecting the characterisation of juvenile (pre-anthesis) plant stress responses undertaken in controlled environments to field agronomic performance is a challenge. The oilseed crop Camelina sativa (camelina), with its innate resilience and plasticity, presents an opportunity to understand both...

2026-02-09 | MTBLS9839 | MetaboLights
ProteomicsCoordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance
Phenotypic plasticity has emerged as an important mechanism of therapy resistance in cancers, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model for endocrine resistance, we show that hormone resistance is associated with enhanced phenotypic pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-05-24 | MSV000083857 | MassIVE
TranscriptomicsEvaluation of phenotypic plasticity in Rana temporaria tadpole development
Traditionally, the study of evolution has focused on heritable variation, because selection on non-heritable phenotypic variation was deemed non-important for its inability to cause evolutionary responses such as diversification of lineages. Recently however, it has been suggested that also environm...
ORGANISM(S): Rana temporaria 
2014-03-18 | E-GEOD-42274 | biostudies-arrayexpress
TranscriptomicsRapid evolution of phenotypic plasticity and shifting thresholds of genetic assimilation in the nematode Caenorhabditis remanei
Many organisms can acclimate to new environments through phenotypic plasticity, a complex trait that can be heritable, subject to selection, and evolve. However, the rate and genetic basis of plasticity evolution remain largely unknown. We experimentally evolved outbred populations of the nematode C...
ORGANISM(S): Caenorhabditis remanei 
2014-05-04 | E-GEOD-56510 | biostudies-arrayexpress
TranscriptomicsGenes enabling phenotypic plasticity evolve canalized gene expression by their limited associations with transcriptional regulators
Global climate change increasingly polarizes environments, presenting unprecedented challenges to many organisms (Smol, 2012). Polarization occurs not only in the spatial dimension, producing greater desert drought and tropical rainfall, for example, but also in the temporal dimension by making a lo...
ORGANISM(S): Fundulus heteroclitus 
2014-10-02 | E-GEOD-47035 | biostudies-arrayexpress
ProteomicsID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche
Spontaneously transformed mouse ovarian surface epithelial cell line ID8 generates a syngeneic mouse model, frequently used in pre-clinical evaluation. Towards a precise, subtype-specific perspective of such applications, we thought it pertinent to study its stratification into a specific molecular ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD060359 | Pride
Phenotypic plasticity D8 Ascites. 
GenomicsThe evolution of phenotypic plasticity in response to temperature stress
The evolution of phenotypic plasticity in response to temperature stress
PRJEB41008 | ENA
ProteomicsProteomic analysis of Adnp mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090257 | MassIVE
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