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MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
ProteomicsLabel-free quantitative plasma membrane proteome analysis of Candida glabrata wild-type and Cgvps34∆ (lacks phosphatidylinositol 3- phosphate kinase, CgVps34) strains. Label-free quantitative plasma membrane proteome analysis of Candida glabrata wild-type and Cgvps34∆ (lacks phosphatidylinositol 3- phosphate kinase, CgVps34) strains.
The project is aimed at characterizing the effect of loss of phosphatidylinositol 3- phosphate kinase (CgVps34) on the plasma membrane proteome of Candida glabrata.
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2024-02-19 | PXD042056 | Pride
Plasma membrane (pm) Pi3k (phosphatidylinositol 3- phosphate kinase) Candida glabrata Label-free quantitative proteome analysis 
ProteomicsIn vitro reconstitution of Sgk3 activation by phosphatidylinositol-3-phosphate
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid 19 phosphatidylinositol-3-phosphate (PI3P) downstream of growth factor signaling and 20 by Vps34-mediated PI3P production during autophagy. Upregulation of Sgk3 activity 21 has been linked to a number of human cance...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025327 | Pride
Kinase Sgk3 Hdx-ms Pi3p 
ProteomicsPhosphatidylinositol 3-phosphate (PI3P) interactome analysis under varied iron conditions in Candida glabrata.
The project is aimed at identifying proteins that interact with PI3P in low-iron, regular-iron and high-iron grown Candida glabrata cells.
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2024-02-19 | PXD042058 | Pride
Bathophenanthroline disulfonate (bps) Lc-ms/ms. Candida glabrata Phosphatidylinositol 3-phosphate (pi3p) 
GenomicsPhosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane
Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane
PRJNA1330818 | ENA
UnknownMechanism of substrate specificity of phosphatidylinositol phosphate kinases.
Not available
S-EPMC4978281 | biostudies-literature
UnknownStructural basis for phosphatidylinositol-phosphate biosynthesis.
Not available
S-EPMC4634129 | biostudies-literature
TranscriptomicsNuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage [expression]
ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 sele...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-47645 | biostudies-arrayexpress
TranscriptomicsNuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage [ChIP-chip]
ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 sele...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-47688 | biostudies-arrayexpress
UnknownStructural and Functional Characterization of Phosphatidylinositol-Phosphate Biosynthesis in Mycobacteria.
Not available
S-EPMC7483940 | biostudies-literature
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