Sort   by:  
 Page size 
ProteomicsGlobal Phospho-Proteomic Profiling of Pathway-Level Molecular Alterations in Barrett’s Esophagus
In the present study, we applied deep, quantitative mass-spectrometry to clinical samples (Barrett’s esophagus and matched adjacent normal biopsies) to gain a mechanistic understanding of the molecular pathways associated with disease progression. From our rich LC/MS profiles, we identified a robust...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD023293 | Pride
Biopsy  systems biology  mass spectrometry  disease signature 
ProteomicsDeciphering hepatitis B virus phospho-signature in primary human hepatocytes
Phosphorylation is a major post-translation modification (PTM) of proteins, and small molecules, which is finely tuned by the activity of several hundred kinases and phosphatases. It controls most if not all cellular pathways including anti-viral responses. Accordingly, viruses often induce importan...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus subtype ayw 
2024-05-02 | PXD051216 | Pride
Phosphorylation Hepatitis b virus Nanolc-ms/ms Primary hepatocytes 
ProteomicsThe cardiac phospho-proteome during pressure overload in mice
Trans-aortic constriction (TAC) is a widely used murine model to study pressure overload-induced cardiac hypertrophy and heart failure. Despite its high prevalence during aortic stenosis or chronic arterial hypertension, the global alterations in cardiac proteome and phospho-proteome dynamics follow...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD061784 | Pride
Heart failure Cardiac remodelling Signalling Tac Phosphorylation 
UnknownAutomated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality.
Not available
S-EPMC4114438 | biostudies-literature
ProteomicsGlobal Hyper-Phosphorylation Characterizes Liver Disease Progression in Methionine Adenosyltransferase 1A Knockout Mice
Methionine adenosyltransferase 1a (Mat1a) is responsible for hepatic biosynthesis of S-adenosyl-L-methionine (SAMe), the principal cellular methyl donor. Mat1a -/- mice have decreased hepatic SAMe levels, and spontaneously develop nonalcoholic steatohepatitis (NASH) which can be reversed with exogen...
ORGANISM(S): Homo Sapiens Mus Musculus 
2026-06-12 | PXD022122 | panorama
UnknownCandidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics.
Not available
S-EPMC10631096 | biostudies-literature
ProteomicsAntibody profiling of smallpox vaccinees with/without a 'take' using custom vaccinia virus proteome microarrays
Successful vaccination against smallpox with conventional vaccinia virus is usually determined by the development of a vesicular skin lesion at the site of vaccinia inoculation, called a ‘take’. Although previous vaccination is known to be associated with attenuation of the take, the immunology t...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-34931 | biostudies-arrayexpress
ProteomicsActive zone plasticity drives presynaptic dephosphorylation in Drosophila
The function of the nervous system relies on tightly regulated, yet plastic synaptic vesicle release machinery at the presynaptic active zone. In Drosophila, a form of presynaptic active zone plasticity, Presynaptic Scaling, or PreScale, is executed by the ELKS-family scaffold protein Bruchpilot (BR...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-06-09 | PXD067034 | Pride
Bruchpilot (brp) Phospho-proteomics Drosophila Presynaptic scaling Prescale Proteomics 
ProteomicsMultimodal measurement of the transcriptome and proteome in G2/M arrested single cells using nanoSPLITS
Single-cell proteomic data from RO-3306 treated alveolar type II epithelial cells (C10) and untreated C10 cells. Cells were sorted using cellenONE onto several nanoSPLITS chips. Cell lysates were then split for parallel RNAseq and proteomic analysis. For proteomics recovery experiment where both chi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-02 | MSV000090828 | MassIVE
ProteomicsMultimodal measurement of the transcriptome and proteome from dissociated human pancreatic islet cells using nanoSPLITS
Human pancreatic islets from two human donors (Prodo Laboratories) were acquired and cultured for 24 hr in pancreatic islet media (PIMS, Prodo Laboratories). Single cells were dissociated with TrypLE for ~15-30 minutes, washed with PBS, stained with Calcein-AM/propidium iodide, and sorted onto nanoS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-07 | MSV000093330 | MassIVE
Sort   by:  
 Page size