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ProteomicsCharacterization of a mitochondria associated phosphocreatine phosphatase in thermogenic adipocytes
Adaptive thermogenesis has attracted much attention because of its ability to raise systemic energy expenditure and counter obesity and diabetes. Recent data have indicated that thermogenic fat cells utilize creatine to stimulate futile substrate cycling, dissipating chemical energy as heat. This mo...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025032 | Pride
Tnap Thermogenesis Obesity Phosphocreatine Adipocyte 
GenomicsIncreased phosphocreatine/creatine ratio in white adipocytes promotes inflammation
Increased phosphocreatine/creatine ratio in white adipocytes promotes inflammation
PRJNA791244 | ENA
TranscriptomicsIncreased phosphocreatine/creatine ratio in white adipocytes promotes inflammation
The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find that the WAT phosphocreatine/creatine ratio is increased and creatine kinase-B expression ...
ORGANISM(S): Homo sapiens 
2022-01-27 | GSE192361 | GEO
ProteomicsBrain Creatine Kinase as a biomarker for Alzheimer’s disease
The creatine-phosphocreatine cycle serves as a crucial temporary energy buffering system in the brain, regulated by brain creatine kinase (CKB). CKB, responsible for reversible phosphorylation of creatine, plays a pivotal role in maintaining ATP levels. Alzheimer's disease (AD) has been linked to in...
ORGANISM(S): Homo Sapiens 
2024-07-03 | PXD050060 | panorama
TranscriptomicsTranscription profiling of mouse ERRalpha wild type vs. knockout hearts, baseline
We hypothesized that the estrogen-related receptor a (ERRa), which recruits PGC-1a to metabolic target genes in heart, exerts protective effects in the context of stressors known to cause heart failure. ERRa-/- mice subjected to left ventricular (LV) pressure overload developed signatures of heart f...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8106 | biostudies-arrayexpress
UnknownImpaired phosphocreatine metabolism in white adipocytes promotes inflammation.
Not available
S-EPMC8885409 | biostudies-literature
GenomicsDepletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system
Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system
PRJNA901484 | ENA
UnknownMitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Not available
S-EPMC8287965 | biostudies-literature
MetabolomicsUrine Latin Square Spike-In for testing the NMR quantification tool, MetaboQuant
To test the quantification performance of MetaboQuant and other NMR quantification tools, a set of eight metabolites were added to replicates of a urine sample in varying concentrations. The metabolites were alanine, creatinine, histidine, betaine, acetate, phosphocreatine, β-hydroxybutyrate (BHBA) ...
2013-01-10 | MTBLS25 | MetaboLights
UnknownDifferentiating Creatine and Phosphocreatine In Vivo Using 3 T 1H MR Spectroscopy.
Not available
S-EPMC12850560 | biostudies-literature
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