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TranscriptomicsIntegrated multi-omics reveals mTOR-LPL-driven dysregulated lipid metabolism induces neuronal hyperexcitability in human microglia of tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by heterozygous pathogenic variants in either TSC1 or TSC2. Emerging evidence suggests a connection between microglia activation and epilepsy as well as cognitive impairment in TSC patients. However, the impact of the causal v...
ORGANISM(S): Homo sapiens 
2023-09-27 | GSE244091 | GEO
ProteomicsPhosphoproteomics of mouse cardiomyocytes reveals signalling pathways triggered by a vasodilator cryptide
Animal venoms are natural sources of bioactive molecules such as cryptides that consist in biological active peptides released after proteolytic cleavage of a peptide or protein precursor. The KPP is a cryptided derived from the c-terminal of an hypotensin (TsHpI) a peptide isolated from the venom o...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD015068 | Pride
Hipotensins Venome Scorpion Cryptide Cardiomyocytes Phosphopreteomics 
GenomicsIntegrated multi-omics reveals mTOR-LPL-driven dysregulated lipid metabolism induces neuronal hyperexcitability in human microglia of tuberous sclerosis complex
Integrated multi-omics reveals mTOR-LPL-driven dysregulated lipid metabolism induces neuronal hyperexcitability in human microglia of tuberous sclerosis complex
PRJNA1021215 | ENA
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