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MetabolomicsPhosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma

Pmk1, a highly conserved pathogenicity-related mitogen-activated protein kinase (MAPK) in pathogenic fungi, is phosphorylated and activated by MAP2K and acts as a global regulator of fungal infection and invasive growth by modulating downstream targets. However, the hierarchical CcPmk1 regulatory...

2022-07-11 | MTBLS4463 | MetaboLights
MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
ProteomicsPhosphoproteomic analysis of thermomorphogenic responses in Arabidopsis
To identify early regulators of plant thermo-responsiveness, we performed phosphoproteomic analysis using TMT (Tandem Mass Tags) labeling and phospeptide enrichment with dark-grown Arabidopsis wild-type seedlings treated with or without 3 hours of warm temperatures (29°C).
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-17 | PXD027094 | Pride
Phosphoproteomics Hypocotyl growth Warm temperature Arabidopsis Thermomorphogenesis 
ProteomicsPhosphoproteomic analysis of thermomorphogenic responses in Arabidopsis
To identify early regulators of plant thermo-responsiveness, we performed phosphoproteomic analysis using TMT (Tandem Mass Tags) labeling and phospeptide enrichment with dark-grown Arabidopsis wild-type seedlings treated with or without 3 hours of warm temperatures (29°C).
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-17 | PXD027095 | Pride
Phosphoproteomics Hypocotyl growth Warm temperature Arabidopsis Thermomorphogenesis 
GenomicsNetwork-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis
Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis
PRJNA930770 | ENA
ProteomicsPhosphoproteomic Analysis Defines BABAM1 as mTORC2 Downstream Effector Promoting DNA Damage Response in Glioblastoma Cells
Glioblastoma (GBM) is a devastating primary brain cancer with a poor prognosis. GBM is associated with an abnormal mechanistic target of rapamycin (mTOR) signaling pathway, consisting of two distinct kinase complexes: mTORC1 and mTORC2. The complexes play critical roles in cell proliferation, surviv...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD033325 | Pride
Phosphoproteomics Mtorc2 Glioblastoma Babam1 Dna damage 
ProteomicsQuantitative proteomic and phosphoproteomic analysis of the liver of the Xizang plateau frog
Protein abundance changes and reversible protein phosphorylation (RPP) play important roles in regulating hypometabolism but have never been documented in overwintering frogs at high altitudes. To test the hypothesis that protein abundance and protein phosphorylation change in response to winter hib...
ORGANISM(S): Nanorana parkeri 
2024-05-22 | PXD042165 | Pride
Metabolism Reversible protein phosphorylation Phosphoproteomic Nanorana parkeri Proteomic Hibernation 
ProteomicsQuantitative phosphoproteomic for CDKL5 substrates
Global phosphoproteomic screen to identify the first cellular substrates of CDKL5. CDKL5 knock-out U2OS cells and CDKL5 wt U2OS cells were generated for the TMT-based phosphoproteomic. Thi leads to the identification and further validation of several phosphopetides of MAP1S, CEP131 and CDKL5 itself....
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD009374 | Pride
Cdkl5 substrates Phosphoproteomic Tmt Ms2 
ProteomicsPhosphoproteomic analysis of mammalian infective Trypanosoma brucei subjected to heat shock suggest atypical mechanisms for thermotolerance
A phosphoproteomic analysis of heat shock response in the mammalian infective bloodstream form Trypanosoma brucei was conducted using SILAC-based quantitation. Treatment at 41 0C for 1h produced significantly altered phosphorylation at 193 sites and significantly altered the abundance of 20 proteins...
ORGANISM(S): Trypanosoma brucei 
2020-03-31 | PXD016482 | Pride
Ls-ms/ms Silac Heat shock Fe-imac 
UnknownProtocol for the processing and downstream analysis of phosphoproteomic data with PhosR.
Not available
S-EPMC8190506 | biostudies-literature
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