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ProteomicsPhosphorylated RNAPII interactome via 4H8 antibody IP
4H8 pull down of chromatin-associated proteins in the Flp-In T-REx HEK293 parental cell line. Phosphorylated RNAPII interactome was measured in three conditions; Untreated, 1mM H2O2 treatment for 15minutes, and 1 hour recovery
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD067969 | Pride
4h8 Interactome Phosphorylated rnapii 
ProteomicsPhosphorylated RNAPII interactome via 4H8 antibody IP with OGG1 inhibitor
RNAPII pull down of chromatin associated proteins in the Flp-In T-REx HEK293 parental cell line. Phosphorylated RNAPII interactome was measured in six conditions; Untreated (with and without OGG1i), 1mM H2O2 treatment for 15minutes (with and without OGG1i) and 2 hours recovery following media washo...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD070086 | Pride
Ogg1i 4h8 Interactome Phosphorylated rnapii 
TranscriptomicsHDACs and Phosphorylated Pol II CTD recruit Spt6 for cotranscriptional histone reassembly
Spt6 is a multifunctional histone chaperone involved in the maintenance of chromatin structure during elongation by RNA polymerase II (Pol II). Spt6 has a tandem SH2 (tSH2) domain within its C-terminus that recognizes Pol II CTD peptides phosphorylated on Ser2, Ser5 or Try1 in vitro. Deleting the tS...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-25 | E-GEOD-61713 | biostudies-arrayexpress
ProteomicsRNA Polymerase II interactome in presence or absence of SCAF1 in U2OS-SCAF1-AID cells
Transcripts produced by RNA polymerase II (RNAPII) are fundamental for cellular responses to environmental changes. It is therefore no surprise that there exist multiple avenues for the regulation of this process. To explore the regulation mediated by RNAPII-interacting proteins, we used an siRNA-ba...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD054675 | Pride
Scaf1-depletion Interactome Rnapii 
UnknownDistinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1-BARD1 complex.
Not available
S-EPMC12805184 | biostudies-literature
TranscriptomicsChIP-chip by array of yeast to determine genome-wide occupancy profiles for RNA polymerase (Pol) II, its phosphorylated forms, and transcription factors
To investigate the chromatin transcription cycle, we determined genome-wide occupancy profiles for RNA polymerase (Pol) II, its phosphorylated forms, and transcription factors in growing yeast. ChIP-chip was performed to identify the genomic binding locations for Rpb3, TFIIB, Tfg1, Kin28, Cet1, Spt4...
ORGANISM(S): Saccharomyces cerevisiae 
2010-08-23 | E-TABM-1033 | biostudies-arrayexpress
TranscriptomicsThe C-Terminal Domain of RNA Polymerase II is Modified by Site-Specific Methylation
The Carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) in mammals undergoes extensive post-translational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the transcriptional co-...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-27315 | biostudies-arrayexpress
GenomicsRNAPII ChIP-Sequencing of A.thaliana tfiis mutant lines under heat stress conditions
RNAPII ChIP-Sequencing of A.thaliana tfiis mutant lines under heat stress conditions
PRJNA884835 | ENA
UnknownPhenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription.
Not available
S-EPMC11879057 | biostudies-literature
GenomicsDifferential recruitment of Ser2/5 phosphorylated RPB1, a component of the elongating RNAPII, in Plasmoidium falciparum parasite with disrupted PfNot1.1 (PF3D7_1103800).
Differential recruitment of Ser2/5 phosphorylated RPB1, a component of the elongating RNAPII, in Plasmoidium falciparum parasite with disrupted PfNot1.1 (PF3D7_1103800).
PRJNA596454 | ENA
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