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TranscriptomicseIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Translational regulation plays a critical role in cell growth and proliferation, and its dysregulation results in cancer. Aberrant expression of the mRNA 5’cap-binding protein, eIF4E, has been implicated in cancer development and progression. eIF4E activity is promoted by phosphorylation. Here we sh...
ORGANISM(S): Mus musculus 
2010-08-17 | E-GEOD-17451 | biostudies-arrayexpress
TranscriptomicsMDA-MB-231 eIF4E RIP-CHIP
Cytoplasmic RNA bound to eIF4E was pulled down from MDA-MB-231 cells to determine the influence of radiation on eIF4E mRNA binding 4 samples were analyzed with 3 biological replicates
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-36179 | biostudies-arrayexpress
GenomicsHyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming
Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming
PRJNA420692 | ENA
Proteomics,MultiomicsProtein phosphorylation evolution across 18 fungal species
Protein phosphorylation evolution across 18 fungal species. For each species whole cell extracts were digested separately with trypsin and LysC. Each digest was IMAC enriched and analyzed by LC-MS/MS in technical triplicate on an LTQ Orbitrap Velos using a 120min method. Data was searched against th...
ORGANISM(S): S. Cerevisiae, S. Paradoxus, S. Mikatae, S. Kudriavzevii, S. Bayanus, N. Castellii, C. Glabrata, V. Polyspora, Z. Rouxii, K. Lactis, L. Kluyveri, L. Thermotolerans, L. Waltii, K. Pastoris, M. Guilliermondii, C. Albicans, S. Stipitis, S. Pombe 
2015-12-18 | MSV000079428 | MassIVE
ProteomicsChlorocebus sabaeus vero E6 and and eIF4E(S209A) Vero cells (S209A-Vero) LC-MSMS upon infection by coronavirus PEDV
Two rounds of TMT relative quantitative proteomics were performed to detect cellular factors involved in p-eIF4E regulation of the synthesis of viral proteins.our first round of screening identified differentially expressed proteins in PEDV-infected cells and mock-infected cells; the cellular pathwa...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2023-03-10 | PXD033916 | Pride
Chlorocebus sabaeus vero e6 Pedv And eif4e(s209a) vero cells (s209a-vero) Phosphorylation of eif4e Lc-msms 
GenomicsTranslation efficiency in the pancreatic tumor in response to ketogenic diet and targeting eIF4E phosphorylation
Translation efficiency in the pancreatic tumor in response to ketogenic diet and targeting eIF4E phosphorylation
PRJNA1111414 | ENA
TranscriptomicseIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Translational regulation plays a critical role in cell growth and proliferation, and its dysregulation results in cancer. Aberrant expression of the mRNA 5’cap-binding protein, eIF4E, has been implicated in cancer development and progression. eIF4E activity is promoted by phosphorylation. Here we sh...
ORGANISM(S): Mus musculus 
2010-08-17 | GSE17451 | GEO
ProteomicsProteomics of extracellular matrix from eIF4E deficient mouse mammary fat pad
It was demonstrated that mice with eIF4E that cannot be activated by phosphorylation (S209A) produced extracellular matrix (ECM) less conducive to breast cancer tumor invasion and metastasis. To examine whether this could in part bedue to differences in the protein composition we analyzed the proteo...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD028953 | Pride
Breast cancer Mouse Mammary fat pad Proteome Extracellular matrix Eif4e 
GenomicsMitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)
Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)
PRJNA544328 | ENA
UnknowneIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.
Not available
S-EPMC2922605 | biostudies-literature
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